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Expertise on models to study safety and efficacy of drug delivery to the brain, as well as disease models in vitro or in animals. Expertise on neural stem cells and brain tumour stem cells.

Existing collaborations relevant to drug delivery

N/A

Publications relevant to drug delivery

Siney E.J, Kurbatskaya K, Chatterjee S, Prasannan P, Mudher A, Willaime-Morawek S. Modelling neurodegenerative diseases in vitro: recent advances in 3D iPSC technologies. AIMS Cell and Tissue Engineering, 2018, 2(1): 1-23

Gould J.M, Smith P.J, Airey C.J, Mort E.J, Airey L.E, Warricker F.D.M, Pearson-Farr J.E, Weston E.C, Gould P.J.W, Semmence O.G, Restall K.L, Watts J.A, McHugh P.C, Smith S.J, Dewing J.M, Fleming T.P, Willaime-Morawek S. Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory. PNAS July 31, 2018, 115 (31) E7398-E7407. 

Chen R, Lee W.Y, Zhang X.H, Zhang J.T, Lin S, Xu L.L, Huang B, Yang F.Y, Liu H.L, Wang B, Tsang .LL, Willaime-Morawek S, Li G, Chan H.C, Jiang X. Epigenetic modification of CCL5/CCR1/ERK axis enhances glioma targeting in dedifferentiation-reprogrammed BMSCs. Stem Cell Reports (2017) 8(3):743–757.

Siney E.J., Holden A., Casselden E., Bulstrode H., Thomas G., Willaime-Morawek S. Metalloproteinases ADAM10 and ADAM17 mediate migration and differentiation in Glioblastoma sphere-forming cells. Molecular Neurobiology (2017) 54:3893.  

Vargas-Caballero M, Willaime-Morawek S, Gomez-Nicola D, Perry V.H, Bulters D, Mudher A. The use of human neurons for novel drug discovery in dementia research. Expert Opinion On Drug Discovery (2016) 11(4):355–367. 

Noorani I, Petty G, Hajiesmaeili H, Grundy P, Sharpe G, Willaime-Morawek S, Gatherer M, Thomas G, Nicoll J, Boche D. Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation? The Journal of Pathology: Clinical Research (2015) 1(2) 67-75.

Bulstrode H., Jones L.M., Siney E.J., Sampson J.M., Ludwig A., Gray W.P., Willaime-Morawek S. A-Disintegrin and Metalloprotease (ADAM) 10 and 17 Promote Self-renewal of Brain Tumor Sphere Forming Cells. Cancer Letters (2012) 326:79-87.