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Chair of SIOPE DIPG Network and Registry.

Expertise: Preclinical (combinational) drug screens, convection-enhanced delivery and MRI-guided high intensity focal ultrasound (HIFU) in DIPG, BBB-targeted liposomal drug encapsulation, clinical trials in children, molecular drug imaging (PET imaging of radiolabeled drugs). 

Tumour types: paediatric high-grade glioma, diffuse midline gliomas / DIPG.

Existing collaborations relevant to drug delivery

Prof. Twan Lammers (RWTH Aachen University). Collaboration and development of preclinical research to study different nanoformulations in combination with high-intensity focused ultrasound (HIFU) in models of pediatric high-grade glioma and DIPG.

Prof. Chrit Moonen (University Medical Center Utrecht). Collaboration in preclinical HIFU studies in pediatric and adult high-grade glioma models, for translation to clinical studies.

Prof. Gert Storm (Utrecht and Twente University). Collaboration in preclinical HIFU studies in pediatric and adult high-grade glioma models, for translation to clinical studies.

Prof. Steven Gill, neurosurgery (Bristol NHS / Harley Street Clinic London). Collaboration in the setup of a clinical trial of convection-enhanced drug delivery in DIPG patients.

Prof. Guus van Dongen (VUmc, Amsterdam). Collaboration in PET-drug imaging studies of monoclonal antibodies in preclinical models and patients with high-grade glioma / DIPG.

Prof. Harry Hendrikse (VUmc, Amsterdam). Collaboration in PET-drug imaging studies of small molecules / TKI’s in preclinical models and patients with high-grade glioma / DIPG.

Publications relevant to drug delivery

Sewing ACP, …, van Vuurden DG, …, Hulleman E. Preclinical evaluation of convection-enhanced delivery of liposomal doxorubicin to treat pediatric diffuse intrinsic pontine glioma and thalamic high-grade glioma. J Neurosurg Pediatr. 2017 May;19(5):518-530.

Jansen MH, Veldhuijzen van Zanten SEM, van Vuurden DG, …, Kaspers GL. Molecular Drug Imaging: 89Zr-Bevacizumab PET in Children with Diffuse Intrinsic Pontine Glioma. J Nucl Med. 2017 May;58(5):711-716.

Jansen MH, Lagerweij T, …, van Vuurden DG, …, Hulleman E. Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models. Mol Cancer Ther. 2016 Sep;15(9):2166-2174.

Nailor A, …, van Vuurden DG, …, Kilday JP. Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours. Ecancermedicalscience. 2016 Mar 31;10:630.

Grasso CS, …, van Vuurden DG, …, Monje M. Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med. 2015 Jun;21(6):555-559.

Sewing AC, …, van Vuurden DG, …, Hulleman E. Convection enhanced delivery of carmustine to the murine brainstem: a feasibility study. J Neurosci Methods. 2014 Dec 30;238:88-94.

Veringa SJ, …, van Vuurden DG, …, Hulleman E. In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse intrinsic pontine glioma. PLoS One. 2013 Apr 29;8(4):e61512