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Drug delivery to the brain is one of our key areas of research and we have published extensively in this area. We have developed a polymer based system that increases drug transport either across the BBB or by nose-to-brain administration. For this reason we have been chosen as partner for example for the EU consortium EPITARGET - to deliver epilepsy medication. The system is being commercially developed by Nanomerics.

Existing collaborations relevant to drug delivery

N/A

Publications relevant to drug delivery

Fisusi, FA, Siew, A, Chooi, KW, Okubanjo, O, Garrett, N, Lalatsa, K, et al. (2016) Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels - A Strategy for Brain Cancer Treatments. Pharmaceutical Research, 1–15. http://doi.org/10.1007/s11095-016-1872-x

Lalatsa, A, Schätzlein, AG, Garrett, NL, Moger, J, Briggs, M, Godfrey, L, et al. (2015) Chitosan amphiphile coating of peptide nanofibres reduces liver uptake and delivers the peptide to the brain on intravenous administration. Journal of Controlled Release : Official Journal of the Controlled Release Society, 197, 87–96. http://doi.org/10.1016/j.jconrel.2014.10.028

Uchegbu, IF, Uchegbu, IF, Jones, MC, Jones, MC, Corrente, F, Corrente, F, et al. (2014) The Oral and Intranasal Delivery of Propofol Using Chitosan Amphiphile Nanoparticles. Pharmaceutical Nanotechnology, 2(2), 65-74. https://doi.org/10.2174/2211738502666140616184703

Lalatsa, A, Schätzlein, AG, & Uchegbu, IF (2014) Strategies To Deliver Peptide Drugs to the Brain. Molecular Pharmaceutics, 11(4), 1081–1093. http://doi.org/10.1021/mp400680d

Mazza, M, Notman, R, Anwar, J, Rodger, A, Hicks, M, Parkinson, G, et al. (2013) Nanofiber-based delivery of therapeutic peptides to the brain. ACS Nano, 7(2), 1016–1026. http://doi.org/10.1021/nn305193d

Lalatsa, A, Garrett, NL, Ferrarelli, T, Moger, J, Schätzlein, AG, & Uchegbu, IF (2012) Delivery of peptides to the blood and brain after oral uptake of quaternary ammonium palmitoyl glycol chitosan nanoparticles. Molecular Pharmaceutics, 9(6), 1764–1774. http://doi.org/10.1021/mp300068j