Sarmento, Bruno
Principal Investigator
University of Porto, Portugal
Nanomedicines and Translational Drug Delivery
My research is focused on the development of functionalized nanomedicines for biomedical applications, with particular interest in brain cancer and neurological disorders. I have also specialized in BBB engineering models to validate functionalized nanomedicines and to perform in vitro/in vivo correlation.
Existing collaborations relevant to drug delivery
N/A
Publications relevant to drug delivery
Castro F, Martins C, Silveira MJ, et al. Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments, Advanced Drug Delivery Reviews, in press
Moura R, Pacheco C Pêgo AP, et al. Lipid nanocapsules to enhance drug bioavailability to the central nervous system, Journal of Controlled Release, 322, 390-400, 2020
Pacheco C, Sousa F, Sarmento B. Chitosan-based nanomedicine for brain delivery: Where are we heading? Reactive and Functional Polymers 146, 104430, 2020
Cayero-Otero M, Gomes MJ, Martins C, et al. In vivo biodistribution of venlafaxine-PLGA nanoparticles for brain delivery: Plain vs functionalized nanoparticles, Expert Opinion on Drug Delivery, 16, 1413-1429, 2019
Sousa F, Dhaliwal H, Gattacceca F, et al. Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles, Journal of Controlled Release, 309, 37-47, 2019
Martins C, Araújo F, Gomes MJ, et al. Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy, European Journal of Pharmaceuticals and Biopharmaceuticals, 138, 111-124, 2019
Moura R, Martins C, Pinto S, et al. Blood-Brain Barrier receptors and transporters: An insight on their function and how to exploit them through nanotechnology, Expert Opinion on Drug Delivery, 16, 271-285, 2019
Fernandes C, Pinto M, Martins C, et al. Development of a PEGylated-based platform for efficient delivery of dietary antioxidants across the blood–brain barrier, Bioconjugate Chemistry, 29, 1677-1689, 2018
Moura R, Almeida A, Sarmento B. The role of non-endothelial cells on the penetration of nanoparticles through the blood brain barrier, Progress in Neurobiology, 159, 39-49, 2017
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