Professor of Neuroscience
University of Otago, New Zealand
Ultrasound-mediated targeted drug delivery
I work with a multi-disciplinary team of anatomists, physiologists, clinical pharmacologists, chemists, cancer geneticists, ultrasound and electronics engineers, developing novel approaches to targeted drug delivery to the brain. We have developed and patented a liposome-based non-invasive brain ultrasound drug delivery system which we are in the process of commercialising. This is being developed for the targeted delivery of chemotherapeutic drugs to brain cancers, for anti-seizure drugs in epilepsy, and dopaminergic reinforcement drugs in Parkinson's disease.
Existing collaborations relevant to drug delivery
Publications relevant to drug delivery
Gandhi K, Barzegar-Fallah A, Banstola A. et al. Ultrasound-mediated blood-brain barrier disruption for drug delivery: a systematic review of protocols, efficacy and safety outcomes from preclinical and clinical studies. Pharmaceutics, 14, 833, https://doi.org/10.3390/pharmaceutics14040833, (2022).
Nakano T, Rizwan S, Myint, DMA. et al. An on-demand drug delivery system for control of epileptiform seizures. Pharmaceutics 14, 468, https://doi.org/10.3390/pharmaceutics14020468, (2022).
Mohammad Y, Fallah AB, Reynolds JNJ, et al. Steric stabilisers govern the colloidal and chemical stability but not in vitro cellular toxicity of linoleoylethanolamide cubosomes. Colloids and Surfaces B: Biointerfaces, https://doi.org/10.1016/j.colsurfb.2020.111063, (2020).
Mackay SM, Myint DMA, Easingwood RA, et al. Dynamic control of neurochemical release with ultrasonically sensitive nanoshell-tethered liposomes. Communications Chemistry, vol 2, 122, doi.org/10.1038/s42004-019-0226-0, (2019).
Mujoo H, Reynolds JNJ, Tucker IG. A real-time in vitro assay to evaluate the release of macromolecules from liposomes. Drug Testing and Analysis, 1-8, DOI: 10.1002/dta.2332 (2018).
Hinow P, Radunskaya A, Mackay SM. et al. Signaled drug delivery and transport across the blood-brain barrier. Journal of Liposome Research 26, 233-45 (2016).
Mujoo H, Reynolds JNJ, Tucker IG. The influence of bile salts on the response of liposomes to ultrasound. Journal of Liposome Research, 26, 87-95, DOI: 10.3109/08982104.2015.1019515 (2016).
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