Reynolds, John

Professor of Neuroscience

University of Otago, New Zealand

Ultrasound-mediated targeted drug delivery

I work with a multi-disciplinary team of anatomists, physiologists, clinical pharmacologists, chemists, cancer geneticists, ultrasound and electronics engineers, developing novel approaches to targeted drug delivery to the brain. We have developed and patented a liposome-based non-invasive brain ultrasound drug delivery system which we are in the process of commercialising. This is being developed for the targeted delivery of chemotherapeutic drugs to brain cancers, for anti-seizure drugs in epilepsy, and dopaminergic reinforcement drugs in Parkinson's disease.

Existing collaborations relevant to drug delivery


Publications relevant to drug delivery

Gandhi K, Barzegar-Fallah A, Banstola A. et al. Ultrasound-mediated blood-brain barrier disruption for drug delivery: a systematic review of protocols, efficacy and safety outcomes from preclinical and clinical studies. Pharmaceutics, 14, 833,, (2022).

Nakano T, Rizwan S, Myint, DMA. et al. An on-demand drug delivery system for control of epileptiform seizures. Pharmaceutics 14, 468,, (2022).

Mohammad Y, Fallah AB, Reynolds JNJ, et al. Steric stabilisers govern the colloidal and chemical stability but not in vitro cellular toxicity of linoleoylethanolamide cubosomes. Colloids and Surfaces B: Biointerfaces,, (2020).

Mackay SM, Myint DMA, Easingwood RA, et al. Dynamic control of neurochemical release with ultrasonically sensitive nanoshell-tethered liposomes. Communications Chemistry, vol 2, 122,, (2019).

Mujoo H, Reynolds JNJ, Tucker IG. A real-time in vitro assay to evaluate the release of macromolecules from liposomes. Drug Testing and Analysis, 1-8, DOI: 10.1002/dta.2332 (2018).

Hinow P, Radunskaya A, Mackay SM. et al. Signaled drug delivery and transport across the blood-brain barrier. Journal of Liposome Research 26, 233-45 (2016).

Mujoo H, Reynolds JNJ, Tucker IG. The influence of bile salts on the response of liposomes to ultrasound. Journal of Liposome Research, 26, 87-95, DOI: 10.3109/08982104.2015.1019515 (2016).

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