Marlow, Maria

Pharmacist

University of Nottingham, UK

School of Pharmacy

I am a pharmacist with a PhD in drug delivery and over 18 years’ experience in the pharmaceutical industry, having worked on many different drug delivery options and formulations including oral, intravenous and inhaled dosage forms. In 2012, I made the transition back to academia.

My research is focused on developing drug delivery systems, in collaboration with clinicians that address an unmet clinical need.

My current research projects focus on using injectable hydrogels, nanoparticles and microneedles to deliver small molecules, DNA, proteins or peptides for the treatment of cancer (skin, ovarian and brain tumours), HIV and pain.

Existing collaborations relevant to drug delivery

Ruman Rahman (Nottingham) - Sprayable hydrogels for local delivery (post-surgery)

Ruman Rahman and Stuart Smith (Nottingham) - Long acting nanocomposite materials for intrathecal delivery      

Marianne Ashford (AstraZeneca) - Hydrogel Formulations for Intraperitoneal Delivery for Ovarian Cancer 

Professor Maria Alonso (University of Santiago de Compostella, Spain) - Formulations for Intraperitoneal Delivery for Ovarian Cancer     

Tracey Bradshaw (Nottingham) – Benzothiazoles

Lindy Durrant (Nottingham) - Cancer vaccines.

 

Grants: EPSRC, BBSRC and The Stoneygate Trust.

Publications relevant to drug delivery

Faidra Angelerou, M. G.; Markus, R.; Paraskevopoulou, V.; Foralosso, R.; Clarke, P.; Alvarez, C. V.; Chenlo, M.; Johnson, L.; Rutland, C.; Allen, S.; Brasnett, C.; Seddon, A.; Zelzer, M.; Marlow, M., Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo. Journal of Controlled Release 2020, 317, 118-129.

Sabri, A. H.; Kim, Y.; Marlow, M.; Scurr, D. J.; Segal, J.; Banga, A. K.; Kagan, L.; Lee, J. B., Intradermal and transdermal drug delivery using microneedles – Fabrication, performance evaluation and application to lymphatic delivery. Advanced Drug Delivery Reviews 2019. 

Johnson, L.; Faidra Angelerou, M. G.; Surikutchi, B. T.; Allen, S.; Zelzer, M.; Marlow, M., Low Molecular Weight Nucleoside Gelators: A Platform for Protein Aggregation Inhibition. Molecular Pharmaceutics 2019, 16 (1), 462-467.

Štaka, I.; Cadete, A.; Surikutchi, B. T.; Abuzaid, H.; Bradshaw, T. D.; Alonso, M. J.; Marlow, M., A novel low molecular weight nanocomposite hydrogel formulation for intra-tumoural delivery of anti-cancer drugs. International Journal of Pharmaceutics 2019, 565, 151-161.

Citossi, F.; Smith, T.; Lee, J. B.; Segal, J.; Gershkovich, P.; Stocks, M. J.; Bradshaw, T. D.; Kellam, B.; Marlow, M., Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation. Molecular Pharmaceutics 2018, 15 (4), 1578-1586.

Skilling, K. J.; Stocks, M. J.; Kellam, B.; Ashford, M.; Bradshaw, T. D.; Burroughs, L.; Marlow, M., Nucleoside-Based Self-Assembling Drugs for Localized Drug Delivery. ChemMedChem 2018, 13 (11), 1098-1101.

Skilling, K. J.; Kellam, B.; Ashford, M.; Bradshaw, T. D.; Marlow, M., Developing a self-healing supramolecular nucleoside hydrogel. Soft Matter 2016, 12 (43), 8950-8957.

Marlow, M.; Al-Ameedee, M.; Smith, T.; Wheeler, S.; Stocks, M. J., Linifanib - a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator. Chemical Communications 2015, 51 (29), 6384-6387.

Stone, E. L.; Citossi, F.; Singh, R.; Kaur, B.; Gaskell, M.; Farmer, P. B.; Monks, A.; Hose, C.; Stevens, M. F. G.; Leong, C. O.; Stocks, M.; Kellam, B.; Marlow, M.; Bradshaw, T. D., Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery. Bioorganic & Medicinal Chemistry 2015, 23 (21), 6891-6899.


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