Professor of Membrane Traffic and Drug Delivery
Cardiff University, Wales, UK
School of Pharmacy and Pharmaceutical Sciences
Research projects in my lab fall under cancer cell biology, endocytosis and drug delivery, concentrating on linking knowledge of endocytosis to enhance our capacity to deliver therapeutics across biological barriers to defined regions of cells. We actively collaborate and have recent collaborations with a number of national and international groups including small and major Pharmaceutical Industries. My group has published widely within the fields of endocytosis and drug delivery especially within the remit of early endosomal traffic and the utilization of a variety of delivery systems for enhancing the cellular delivery of therapeutic molecules. These include systems based on polymers, peptides, exosomes and antibodies. I currently sit on the Editorial Board of the Journal of Controlled Release, Membranes, and The Young Darwinian.
Existing collaborations relevant to drug delivery
The School of Pharmacy, Nottingham University; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen; UM Department of Chemistry, Technical University of Munich; Astra Zeneca.
I am also an invited member of this Drug Delivery Consortium: 2018-2022 COST- European cooperation in Science and Technology Delivery of RNA therapy.
Publications relevant to drug delivery
Nödling, A.R, Mills, E.M., Li, X., Cardella, D., Sayers, E.J Wu, S-H., Jones, A.T., Luk, L.Y.P and Tsai, Y-H (2020) Cyanine dyes as drug delivery vectors for mitochondrial targeting. ChemComm 56 (34), 4672-46753.
Wymant, J.M., Sayers E.J., Muir, D., Jones, A.T (2020) Mechanistic characterisation of a trastuzumab mediated crosslinking strategy for driving HER2/3 endocytosis and downregulation in breast cancer. J Cancer 11(11):3288-3302.
Giannakopoulou, N., Williams, J.B, Moody, P.R, Sayers, E., Pope, I., Payne, L., Alexander, C., Jones, A.T., Langbein, W., Watson, P., and Borri, P. (2020) Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells Nanoscale 12(7):4622-4635.
Eissa, N., Birch, D., Sayers, E., Moerck-Nielsen, H. and Jones , A.T. (2020) EJP18, a Novel Cell Penetrating Peptide from the Juxtamembrane Domain of the Epidermal Growth Factor Receptor Biochemical Journal 477 (1) 45-606.
Sayers, E.J., Peel S.E., Schantz, A., England, R.M., Beano, M., Bates, S.M., Desai, A.S., Puri, S., Ashford, M. and Jones, A.T (2019) Influence of endolysosomal pH, localisation and trafficking in multicomponent lipid nanoparticle mediated mRNA delivery across different tumour cell lines. Molecular Therapy 27 (6) 1950-1962.
Woods, B., Döllerer, D., Aikman, B., Wenzel, M., Sayers, E.J., Kühn, F.E., Jones, A.T., Casini, A. (2019) Highly luminescent self-assembled metallacages featuring bispyridyl ligands functionalized with BODIPY for delivery of cisplatin. (2019) J Inorg Biochem; 199:1107818.
Wahlich, J., Desai, A., Greco, Hill, K. Jones, A.T., Mrsny, R., Pasut, G., Perrie, Y., Seib, P., Seymour, L., Uchegbu, I. (2019) Nanomedicines for the delivery of biologicals International Journal of Pharmaceutics Meeting Commentary 11 (5)10. Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines (2019).
Patel, S.G., Sayers, E.J., He, L., Narayan, R., Williams, T., Mills, E.M., Allemann, R.K., Luk, L.Y.P., Jones, A.T*., Tsai, Y-H*. Scientific Reports. *Joint Corresponding authors. 9 (1): 6298.
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