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My research area covers advanced MRI techniques for improved diagnosis and monitoring of treatment response in paediatric cancer. I specialize in the development of new imaging techniques for measuring the cellular and vascular structure of paediatric brain tumours. I am currently leading the integration of these techniques into clinical practice at Great Ormond Street Children's Hospital. Using these techniques, we can monitor the blood supply to a tumour, which will have a strong influence on the efficacy of drug delivery. Changes in the tumour microstructure as a response to treatment can also be measured.

Existing collaborations relevant to drug delivery

N/A

Publications relevant to drug delivery

Hales et al. Delineation of the visual pathway in paediatric optic pathway glioma patients using probabilistic tractography, and correlations with visual acuity. NeuroImage Clinical (Oct 2017), In Press

Hales PW et al. A multi-Gaussian model for apparent diffusion coefficient histogram analysis of Wilms’ tumour subtype and response to chemotherapy. NMR in Biomedicine, 2015 Aug, 28(8): 948-957.

Grech-Sollars M, Hales PW et al. Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain. NMR in Biomedicine, 2015 Apr, 28(4): 468–485.

Hales PW et al. A two-stage model for in vivo assessment of brain tumor perfusion and abnormal vascular structure using arterial spin labeling. PLoS ONE 2013 Oct; 8(10): e75717.

Hales PW et al. Combined arterial spin labeling and diffusion-weighted imaging for noninvasive estimation of capillary volume fraction and permeability-surface product in the human brain. J Cereb Blood Flow Metab. 2013 Jan; 33(1): 67-75