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My Lab uses in vitro blood-brain barrier models to assess and improve CNS drug delivery. We currently use an in vitro model of the human BBB and we are developing BBB models using induced pluripotent stem cells (iPSCs).

Existing collaborations relevant to drug delivery

 I collaborate with more than 60 partners worlwide, including academics and private companies.

Publications relevant to drug delivery

Heymans M, Figueiredo R, Dehouck L, et al. Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells. Fluids Barriers CNS. 2020 Jul 28;17(1):48.

Nolay F, Sevin E, Létévé M, et al. First step to the improvement of the blood brain barrier passage of atazanavir encapsulated in sustainable bioorganic vesicles. Int J Pharm. 2020 Jul 11:119604.

Baati R, Jagadeesh Y, Dias J, et al. Chemoselective Hydrogenation of 6-alkynyl-3-fluoro-2-pyridinaldoxime: Access to first-in-class 6-alkyl-3-Fluoro-2-pyridinaldoxime as Reactivator of Sarin-Inhibited AChE with increased BBB Permeability. Chemistry. 2020 Jul 6. 

Mora Lagares L, Minovski N, Caballero Alfonso AY, et al. Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies. Int J Mol Sci. 2020 Jun 5;21(11):E4058.

Calas AG, Hanak AS, Jaffré N, et al. Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime. Biomolecules. 2020 Jun 4;10(6):E858.

Di Biase E, Lunghi G, Maggioni M, et al. GM1 Oligosaccharide Crosses the Human Blood-Brain Barrier In Vitro by a Paracellular Route. Int J Mol Sci. 2020 Apr 19;21(8):E2858