Evans, Stephen

University of Leeds, UK

Expertise in:

1. Developing Therapeutic Microbubbles, as theranostic agents, for enhanced, targeted drug delivery to cancers.

2. Nanobubble loaded Liposomes for Drug Delivery

Existing collaborations relevant to drug delivery

AF Markham, PL Coletta: preclinical models for colorectal cancer

David Jayne: New in vitro Models for Cancer treatment

S Freear, J Mclaughlin Ultrasound based bubble disruption for enhancing drug uptake

Zhan Ong  Drug delivery for Glioblastoma

Jon Sandoe : Bubbles plus ultrasound for treatment of infection

Publications relevant to drug delivery

Smith E, Nie L, McLaughlan J, et al. An Open Access Chamber Designed for the Acoustic Characterisation of Microbubbles. Applied Sciences 2022;12(4) doi: 10.3390/app12041818

Roach L, Coletta PL, Critchley K, et al. Controlling the Optical Properties of Gold Nanorods in One-Pot Syntheses. The Journal of Physical Chemistry C 2022 doi: 10.1021/acs.jpcc.1c10447

Newham G, Evans SD, Yuin Ong Z. Mechanically Tuneable Physical Nanocomposite Hydrogels from Polyelectrolyte Complex Templated Silica Nanoparticles for Anionic Therapeutic Delivery. Journal of Colloid and Interface Science 2022 doi: 10.1016/j.jcis.2022.02.052

Lin CC, Suen KM, Jeffrey PA, et al. Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state. Mol Cell 2022;82(6):1089-106 e12. doi: 10.1016/j.molcel.2022.02.005 [published Online First: 2022/03/02]

Kpeglo D, D. G. Hughes M, Dougan L, et al. Modeling the Mechanical Stiffness of Pancreatic Ductal Adenocarcinoma. Matrix Biology Plus 2022 doi: 10.1016/j.mbplus.2022.100109

Ingram N, McVeigh LE, Abou-Saleh RH, et al. A Single Short 'Tone Burst' Results in Optimal Drug Delivery to Tumours Using Ultrasound-Triggered Therapeutic Microbubbles. Pharmaceutics 2022;14(3) doi: 10.3390/pharmaceutics14030622 [published Online First: 2022/03/27]

Caudwell JA, Tinkler JM, Johnson BRG, et al. Protein-conjugated microbubbles for the selective targeting of S. aureus biofilms. Biofilm 2022;4 doi: 10.1016/j.bioflm.2022.100074

Salim SA, Kamoun EA, Evans S, et al. Novel oxygen-generation from electrospun nanofibrous scaffolds with anticancer properties: synthesis of PMMA-conjugate PVP–H2O2 nanofibers, characterization, and in vitro bio-evaluation tests. RSC Advances 2021;11(33):19978-91. doi: 10.1039/d1ra02575a

Salim SA, Kamoun EA, Evans S, et al. Mercaptopurine-Loaded Sandwiched Tri-Layered Composed of Electrospun Polycaprolactone/Poly(Methyl Methacrylate) Nanofibrous Scaffolds as Anticancer Carrier with Antimicrobial and Antibiotic Features: Sandwich Configuration Nanofibers, Release Study and in vitro Bioevaluation Tests. Int J Nanomedicine 2021;16:6937-55. doi: 10.2147/IJN.S332920 [published Online First: 2021/10/28]

Roach L, Booth ME, Ingram N, et al. Evaluating Phospholipid-Functionalized Gold Nanorods for In Vivo Applications. Small 2021;17(13):e2006797. doi: 10.1002/smll.202006797 [published Online First: 2021/03/09]

Newham G, Mathew RK, Wurdak H, et al. Polyelectrolyte complex templated synthesis of monodisperse, sub-100 nm porous silica nanoparticles for cancer targeted and stimuli-responsive drug delivery. J Colloid Interface Sci 2021;584:669-83. doi: 10.1016/j.jcis.2020.10.133 [published Online First: 2020/11/24]

Charalambous A, Mico V, McVeigh LE, et al. Targeted microbubbles carrying lipid-oil-Nanodroplets for ultrasound-triggered delivery of the hydrophobic drug, Combretastatin A4. Nanomedicine 2021:102401. doi: 10.1016/j.nano.2021.102401 [published Online First: 2021/04/25]

Batchelor DVB, Armistead FJ, Ingram N, et al. Nanobubbles for therapeutic delivery: Production, stability and current prospects. Current Opinion in Colloid & Interface Science 2021;54 doi: 10.1016/j.cocis.2021.101456

Bao P, Paterson D, Peyman S, et al. Textures of Nematic Liquid Crystal Cylindric-Section Droplets Confined by Chemically Patterned Surfaces. Crystals 2021;11(1) doi: 10.3390/cryst11010065

Abou-Saleh RH, Armistead FJ, Batchelor DVB, et al. Horizon: Microfluidic platform for the production of therapeutic microbubbles and nanobubbles. Rev Sci Instrum 2021;92(7):074105. doi: 10.1063/5.0040213 [published Online First: 2021/08/04]

Ye S, Connell SD, McLaughlan JR, et al. One‐Step Preparation of Biocompatible Gold Nanoplates with Controlled Thickness and Adjustable Optical Properties for Plasmon‐Based Applications. Advanced Functional Materials 2020 doi: 10.1002/adfm.202003512

Ye S, Azad AA, Chambers JE, et al. Exploring High Aspect Ratio Gold Nanotubes as Cytosolic Agents: Structural Engineering and Uptake into Mesothelioma Cells. Small 2020:e2003793. doi: 10.1002/smll.202003793 [published Online First: 2020/10/27]

Scott C, Kankanala J, Foster TL, et al. Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. PLoS Pathog 2020;16(8):e1008716. doi: 10.1371/journal.ppat.1008716 [published Online First: 2020/08/12]

Moorcroft SCT, Roach L, Jayne DG, et al. Nanoparticle-Loaded Hydrogel for the Light-Activated Release and Photothermal Enhancement of Antimicrobial Peptides. ACS Appl Mater Interfaces 2020 doi: 10.1021/acsami.9b22587 [published Online First: 2020/04/22]

Kirkby CJ, Gala de Pablo J, Tinkler-Hundal E, et al. Developing a Raman spectroscopy-based tool to stratify patient response to pre-operative radiotherapy in rectal cancer. Analyst 2020 doi: 10.1039/d0an01803a [published Online First: 2020/11/13]

Julia Gala de Pablo DRC, Carrie A. Ambler,   Sally A. Peyman,   Andrew Whiting  and  Stephen D. Evans*. Detection and time-tracking activation of a photosensitiser on live single colorectal cancer cells using Raman spectroscopy. Analyst 2020 doi: 10.1039/D0AN01023E10.1039/x0xx00000x

Ingram N, McVeigh LE, Abou-Saleh RH, et al. Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues. Theranostics 2020;10(24):10973-92. doi: 10.7150/thno.49670 [published Online First: 2020/10/13]

Bourn MD, Batchelor DVB, Ingram N, et al. High-throughput microfluidics for evaluating microbubble enhanced delivery of Cancer therapeutics in spheroid cultures. J Control Release 2020 doi: 10.1016/j.jconrel.2020.06.011 [published Online First: 2020/06/21]

Batchelor DVB, Abou-Saleh RH, Coletta PL, et al. Nested Nanobubbles for Ultrasound-Triggered Drug Release. ACS Appl Mater Interfaces 2020 doi: 10.1021/acsami.0c07022 [published Online First: 2020/06/06]

Armistead FJ, Gala De Pablo J, Gadelha H, et al. Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells. Sci Rep 2020;10(1):3254. doi: 10.1038/s41598-020-59952-x [published Online First: 2020/02/26]

Abou-Saleh RH, Delaney A, Ingram N, et al. Freeze-Dried Therapeutic Microbubbles: Stability and Gas Exchange. ACS Applied Bio Materials 2020 doi: 10.1021/acsabm.0c00982

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