Dandapani, Madhumita

Clinical Associate Professor

University of Nottingham, UK

Paediatric Oncology

I have been a Consultant Paediatric oncologist with clinical expertise in paediatric solid tumours and brain tumours in Nottingham since 2016 and was appointed as Clinical Associate Professor at the University of Nottingham in March 2019. I obtained my PhD in 2012 in cancer cell signalling from the University of Dundee. I have since developed a research niche in tumour metabolism, particularly in childhood brain tumours. I have written clinical trials including PHITT (Paediatric Hepatic International Tumour Trial) and I am co-Investigator on this study. I am a member of the SIOPEL (International Society of Paediatric Oncology Liver group) and on the SIOP Scientific Advisory board for liver tumours. I am the NIHR CRN lead for Paediatric Oncology in the East Midlands and Principal Investigator on several clinical trials. My career aim is to develop novel therapies for children with cancer and to improve outcomes for children with cancer in developing countries.

Existing collaborations relevant to drug delivery

CCLG Little Princess Project Grant - Exploring alterations in amino acid metabolism as novel therapeutic targets in paediatric glial tumours using advanced metabolomics methods.

Publications relevant to drug delivery

Carceller F… Dandapani M… Hargrave DR et al. (2017) Outcome of children and adolescents with central nervous system tumors in phase I trials. J Neurooncol. Dec 13. doi: 10.1007/s11060-017-2698-z

Vardon A, Dandapani M et al. (2017) Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies. Oncotarget. Jun 29; 8(38):63506-63517. doi: 10.18632/oncotarget.18843. eCollection 2017 Sep 8

Carceller F… Dandapani M… Hargrave DR et al. (2016) Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: An Innovative Therapies for Children with Cancer study. Eur J Cancer. Nov; 67: 130-140. doi: 10.1016/j.ejca.2016.08.008. Epub 2016 Sep 21.

Main C, Dandapani M et al (2016) The effectiveness and safety of proton beam radiation therapy in children with malignant central nervous system (CNS) tumours: protocol for a systematic review. Syst Rev. Jul 27; 5(1):124. doi: 10.1186/s13643-016-0285-6.

Dandapani M, Carmela de Santo, Francis Mussai (2016) Arginine Auxotrophy in Paediatric CNS tumours. Neuro Oncology 18 (Suppl 3); iii170-171  

M Dandapani, D Hobin (2015) G403: Assessing the value of bone marrow aspirate and trephine in identifying metastatic involvement in children with Ewing’s sarcoma: a retrospective single centre experience; Archives of Disease in Childhood 100 (Suppl 3) A165-A166; DOI: 10.1136/archdischild-2015-308599. 

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