Choi, James

Imperial College, London, UK

Department of Bioengineering

Noninvasive and localised drug delivery across the blood-brain barrier using ultrasound and microbubbles.

Existing collaborations relevant to drug delivery

I am currently working on three collaborative projects related to delivering drugs in the brain for paediatric brain cancer, glioblastoma multiforme, and Alzheimer’s disease.

Publications relevant to drug delivery

Sujarittam K, Choi JJ. The relationship between bubble concentration and the acoustic emission energy of separate frequency bands. JASA Express Letters. 2(2):022002. 2022.

Morse SV, Mishra A, Chan TG, T.M. de Rosales R, Choi JJ. Liposome Delivery to the Brain with Rapid Short-Pulses of Focused Ultrasound and Microbubbles. Journal of Controlled Release. 341:605-615. 2022.

Jiang Z, Sujarittam K, Yildiz BI, Dickinson RJ, Choi JJ. Passive Cavitation Detection with a Needle Hydrophone Array. IEEE Trans Ultrason Ferroelectr Freq Control. 69(1):233-240. 2021.

Chan TG, Ruehl C, Morse S, Simon M, Rakers V, Watts H, Aprile FA, Choi JJ, Vilar R. Modulation of amyloid-β aggregation by metal complexes with a dual binding mode and their delivery across the blood-brain barrier using focused ultrasound. Chem Sci. 12:9485-9493. 2021.

Jiang Z, Dickinson RJ, Hall TL, Choi JJ. A PZT-PVDF Stacked Transducer for Short-pulse Ultrasound Therapy and Monitoring. IEEE Trans Ultrason Ferroelectr Freq Control. 68(6):2164-2171. 2021.

Davies HJ, Morse SV, Copping MJ, Sujarittam K, Bourgin VD, Tang MX, Choi JJ. Imaging With Therapeutic Acoustic Wavelets-Short Pulses Enable Acoustic Localization When Time of Arrival is Combined With Delay and Sum. IEEE Trans Ultrason Ferroelectr Freq Control. 68(1):178-190. 2020.

Sujarittam K, Choi JJ. Angular dependence of the acoustic signal of a microbubble cloud. J Acoust Soc Am. 148(5):2958. 2020.

Pouliopoulos AN, Smith CAB, Bezer JH, Ghamrawy A El, Sujarittam K, Bouldin CJ, Morse SV, Tang MX, Choi JJ. Doppler Passive Acoustic Mapping. IEEE Trans Ultrason Ferroelectr Freq Control. 67(12):2692-2703. 2020.

Bezer JH, Koruk H, Rowlands CJ, Choi JJ. Elastic deformation of soft tissue-mimicking materials using a single microbubble and acoustic radiation force. Ultrasound Med Biology. 46(12):3327-3338. 2020.

Morse SV, Boltersdorf T, Chan TG, Gavins FNE, Choi JJ, Long NJ. In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia. RSC Chem Biol. 1:385-389. 2020. [2021 Editor’s Choice]

Morse SV, Boltersdorf T, Harriss BI, Chan TG, Baxan N, Jung HS, Pouliopoulos AN, Choi JJ, Long NJ. Neuron labeling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain via focused ultrasound. Theranostics. 10(6):2659-2674. 2020.

Morse SV, Pouliopoulos AN, Chan TG, Copping MJ, Lin J, Long NJ, Choi JJ. Rapid short pulse ultrasound delivers drugs uniformly across the murine blood-brain barrier with negligible disruption. Radiology. 291(2):459-466. 2019.

Koruk H, Choi JJ. Displacement of a bubble located at a fluid-viscoelastic medium interface. J Acoust Soc Am Exp Lett. 2019

El Ghamrawy A, de Comtes F, Koruk H, Mohammed A, Jones JR, Choi JJ. Acoustic Streaming in a Soft Tissue Microenvironment. Ultrasound Med Biol. 45(1):208-217. 2019.

Saharkhiz N, Koruk H, Choi JJ. The effects of ultrasound parameters and microbubble concentration on acoustic particle palpation. J Acoust Soc Am. 144 (2), 796-805. 2018.

Chan TG, Morse SV, Copping MJ, Choi JJ, Vilar R. Targeted Delivery of DNA-Au Nanoparticles across the Blood-Brain Barrier Using Focused Ultrasound. ChemMedChem. 2018.

Koruk H, Choi JJ. Displacement of a bubble by acoustic radiation force into a fluid-tissue interface. J Acoust Soc Am. 143(4):2535. 2018

Lazarus C, Pouliopoulos AN, Tinguely M, Garbin V, Choi JJ. Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound. J. Acoust. Soc. Am. 142(5). 2017

Heymans SV, Martindale CF, Suler A, Pouliopoulos AN, Dickinson RJ, Choi JJ. Simultaneous Ultrasound Therapy and Monitoring of Microbubble-Seeded Acoustic Cavitation Using a Single-Element Transducer. IEEE Trans Ultrason Ferroelectr Freq Control. 64(8):1234-1244. 2017

Zhang C, Yao ZC, Ding Q, Choi JJ, Ahmad Z, Chang MW, Li JS. Tri-Needle Coaxial Electrospray Engineering of Magnetic Polymer Yolk-Shell Particles Possessing Dual-Imaging Modality, Multiagent Compartments, and Trigger Release Potential. ACS Appl Mater Interfaces. 28;9(25):21485-21495. 2017

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