Professor of Neurosurgery, Ophthalmology, Oncology and Biomedical Engineering
Johns Hopkins University, USA
My neurosurgical brain tumor research team has made significant contributions in the fields of brain tumor immunotherapy and multi-drug treatment. We invented and developed Gliadel® wafers to intraoperatively deliver chemotherapy to brain tumors. This work has been expanded to include local delivery of anti-angiogenic therapies, chemotherapeutic agents and resistance modifiers for primary and metastatic brain tumors. I have also worked with collaborators to develop and synthesize new classes of polymers and microchips for drug delivery.
I have extensive PI/CI experience on brain tumor and neuro-oncology grants. I was Co-Principal Investigator of the NCI Cooperative Agreement for Phase I-II Testing for Brain Tumors, "New Approaches for Brain Tumor Therapy" (CA 62475 and CA 62474 [1994-2008]); and Co-investigator of the NIH "Microchip Drug Delivery System" (RO1 EB006365 [2007-2012]).
I was the Principal Investigator of a National Cooperative Drug Discovery Group (NCDDG CA52857) entitled “Controlled Release Polymers for Brain Tumors”. In 1996 this collaborative research resulted in the first FDA approved new treatment for brain tumors in 23 years.
Tumor type: rodent brain tumor cell lines, established human glioma lines, primary cell lines derived from patient samples.
Existing collaborations relevant to drug delivery
Publications relevant to drug delivery
Kim JE, Patel MA, … Brem H, Pardoll DM, Lim M. Combination therapy with anti-PD-1, anti-TIM-3, and focal radiation results in regression of murine gliomas. Clin Cancer Res. 2017; 23(1): 124-136.
Mathios D,…Brem H, Drew M. Pardoll, Lim M. Anti-PD-1 Anti-Tumor Immunity is Enhanced by Local and Abrogated by Systemic Chemotherapy in GBM. Sci Trans Med, 2016, Dec 21;8(370):370ra180.
Chintakunta R, … Brem H, Kost J. Synthesis, Characterization, and Self-Assembly with Plasmid DNA of a Quaternary Ammonium Derivative of Pectic Galactan and Its Fluorescent Labeling for Bioimaging Application. Carbohydr Polym. 2016 Oct 5;150:308-318.
Zhang F, …Brem H, Tyler B, Kannan RM. Uniform Brain Tumor Distribution and Tumor Associated Macrophage Targeting of Systemically Administered Dendrimers. Biomaterials, 2015 vol. 52 pp. 507-516, PMID 25818456.
Wicks RT, …Brem H. Local delivery of cancer cell glycolytic inhibitors in high grade glioma. Neuro-oncology 17(1): 70-80 (2015).
Mangraviti A, … Brem H, Olivi A, Tyler B, Green JJ. Polymeric Nanoparticles for Non-Viral Gene Therapy Extend Brain Tumor Survival In Vivo. ACS Nano. 2015 Feb 24;9(2):1236-1249.
Upadhyay UM, …Brem H, Cima M. Intracranial Microcapsule Chemotherapy Delivery for the Localized Treatment of Rodent Metastatic Breast Adenocarcinoma in the Brain. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16071-16076.
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