University of Nottingham, UK
More than 25 years' experience in the cancer pharmacology and drug discovery fields investigating antitumour activity and mechanisms of action of NCEs, natural products and novel formulations of test agents to enhance and target drug delivery. Of particular interest are self-assembling small molecule hydrogelators and apoferritin-encapsulated formulations for treatment of intractable, drug-resistant cancers.
Existing collaborations relevant to drug delivery
Professor Neil Thomas, Dr. Lyudmila Turyanska, Professor Anca Pordea, Dr. Pavel Gershkovich (University of Nottingham), Dr. Steven Shnyder, Dr. Paul Loadman (University of Bradford): Apoferritin-encapsulated quantum dots, imidazotetrazine and benzothiazole analogues for diagnosis and treatment of intractable cancers.
Dr. Beth Coyle, Dr. Pavel Gershkovic, Dr. Jeni Luckett (University of Nottingham), Dr. Ali Bieneman, Prof. Stephen Lowis, Dr. Will Singleton (University of Bristol): Development of N3-Propargyl imidazotetranine formulations for Convection Enhanced Delivery to the brain.
Publications relevant to drug delivery
Bouzinab K, Summers H, Stevens MFG, et al. Delivery of temozolomide and N3-propargyl analog to brain tumors using an apoferritin nanocage. Appl Mater Interfaces 12(11), 12609-12617 (2020) doi: 10.1021/acsami.0c01514.
José C. Quilles Junior, Fernanda dos Reis Rocho Carlos, A. Montanari, et al. Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells. RSC Advances 2019 9 36699-36706.
Z Liu, L Turyanska, F Zamberlan, et al. Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells. Nanotechnology 2019 30, 505102. Doi: 10.1088/1361-6528/ab437c.
Kaouthar Bouzinab, Helen Summers, Jihong Zhang, et al. In search of effective therapies to overcome resistance to Temozolomide in brain tumours. Cancer Drug Resistance; special issue Drug Resistance mechanisms in cancer 2019;2: DOI: 10.20517/cdr.2019.64
Alastair F Breen, David Scurr, Maria Letizia Cassioli, et al. Protein encapsulation of experimental anticancer agents 5F 203 and Phortress: towards precision drug delivery. International J Nanomedicine 2019:14 9525–9534. DOI: 10.2147/IJN.S226293
Al-Ani AW, Zhang L, Ferreira L, et al. Listeria innocua Dps as a nanoplatform for bioluminescence based photodynamic therapy utilizing Gaussia princeps luciferase and Zinc protoporphyrin IX. Nanomedicine: Nanotechnology, Biology, and Medicine. 2019. Apr 29. 20:102005. Doi:10.1016/jnano.2019.04.008.
Ivana Štaka; Ana Cadette; Bhanu Teja Surikutchi; et al. A novel low molecular weight nanocomposite hydrogel formulation for intra-tumoural delivery of anti-cancer drugs. International J Pharmaceutics. 2019. Jun 30 565, 151-161. DOI 10.1016/ijpharm.2019.04.070.
AF Breen, G Wells, L Turyanska, TD Bradshaw, Development of novel apoferritin formulations for antitumour benzothiazoles. Cancer Reports 2019 DOI 10.1002/cnr2.1155
KJ Skilling, MJ Stocks, B Kellam, et al. Nucleoside-based self-assembling drugs for localised drug delivery. ChemMedChem 2018, 13 (11) June 6, 1098-1101.
F Citossi, T Smith, L-J Bong, et al. Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation. Molecular Pharmaceutics 2018, Apr 2; 15(4):1578-1586; doi: 10.1021/acs.molpharmaceut.7b01106.
K.J. Skilling, B. Kellam, M. Ashford, T.D. Bradshaw and M. Marlow. Developing a self-healing supramolecular nucleoside hydrogel. Soft Matter 2016, 12, 8950-8957; DOI: 10.1039/C6SM01779G.
David Cousin, Jihong Zhang, Marc G. Hummersone, et al. Antitumor Imidazo[5,1-d]-1,2,3,5-tetrazines: Compounds Modified at the 3-Position overcome Resistance in Human Glioblastoma Cell Lines. MedChemComm, 2016, 7, 2332-2343; DOI: 10.1039/C6MD00384B
EL Stone, F Citossi, R Singh, et al. Antitumour Benzothiazoles 32. D DNA adducts and double strand breaks correlate with activity; synthesis of 5F 203 hydrogels for local delivery. Bioorganic & Medicinal Chemistry 2015, 23, 6891-6899.
Anchala I. Kuruppu, Lei Zhang, et al. An apoferritin based drug delivery system for the tyrosine kinase inhibitor Gefitinib. Advanced Healthcare Materials, 2015 4 (18) 2816-2821; DOI 10.1001/adhm.201500389.
J Zhang, M Hummersone, C S Matthews, MFG Stevens, TD Bradshaw. N3-Substituted temozolomide analogues overcome methylguanine-DNA methyltransferase and mismatch repair precipitating apoptotic and autophagic cancer cell death. Oncology 2015, 88, 28-48.
KJ Skilling, A Ndungu, B Kellam, M Ashford, TD Bradshaw, and M Marlow. Gelation properties of self-assembling N-acyl modified cytidine derivatives. J Mat Chem B 2014, 2, 8412-8417
Ramadhan T Othman, Ioanna Kimishi, et al. Overcoming multiple drug resistance mechanisms in medulloblastoma. Acta Neuropath Comm 2014 2: 57.
Kathryn J. Skilling, Francesca Citossi, Tracey D. Bradshaw, et al. Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications. Soft Matter 2014 10 (2) 237-256.
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