Chair of Molecular Bionics; ICREA Professor
University College London, UK & Institute of Bioengineering of Catalonia-Barcelona Institute of Science and Technology, Spain
Nanomedicine, Cancer targeting, and BBB biophysics
I hold the double appointment as Chair of Molecular Bionics in the Department of Chemistry and the institute of Physics of Living Systems at the University College London, and as ICREA Professor and senior group leader at the Institute of Bioengineering of Catalonia part of the Barcelona Institute of Science and Technology. Several of our activities involve the design of novel carriers to target cancer cells and/or cross the blood-brain barrier. We have developed a workflow of activities that allows the design of super-selective nanocarriers, their study in complex in vitro models and finally the pre-clinical validation in relevant models. (See http://www.molecularbionics.org).
Existing collaborations relevant to drug delivery
Darren Hargrave, Great Ormond Street Hospital and Institute of Child Health UCL.
Prof Simona Parrinello, UCL Cancer Research UK Brain Tumour Centre of Excellence.
Prof Sebastian Brander Neurodegenerative Diseases, UCL Queen Square Institute of Neurology.
Professor Silvia Marino, Centre for Genomics for Child Health Blizard Institute Barts and The London School of Medicine and Dentistry.
Prof. Joan Abbott, Blood-Brain Barrier group at King's college London.
Publications relevant to drug delivery
X Tian, D Moreira-Leite, E Scarpa, S Nyberg, G Fullstone, J Forth, D Lourenco-Matias, A Apriceno, A Poma, A Duro-Castano, M Vuyyuru, L Harker-Kirschneck, A Saric, Z Zhang, P Xiang, B Fang, Y Tian, L Luo, L Rizzello, G Battaglia. On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias Science Adv. 2020, 6 (48), eabc4397
B. Sola-Barrado, D. Moreira-Leite, E. Scarpa, A. Duro-Castano, G. Battaglia. Combinatorial Intracellular Delivery Screening of Anticancer Drugs Mol. Pharmac. 2020, 10.1021/acs.molpharmaceut.0c00791
A. Duro-Castano D. Moreira-Leite, J. Forth, Y. Deng D. Matias , C. Noble-Jesus G. Battaglia*. Designing peptide nanoparticles for efficient brain delivery Adv. Drug Deliv. Rev. 2020, 160, 52-77
M. Liu, A. Apriceno, M. Sipin, E. Scarpa,L. Rodriguez-Arco, A. Poma, G. Marchello,G. Battaglia, S. Angioletti-Uberti*. Combinatorial entropy behaviour leads to range selective binding in ligand receptor interactions Nature Comm. 2020 11, 4836
E. S. Kim , D. Kim , S. Nyberg , A. Poma , D. Cecchin , S. Jain, K. A. Kim , Y. J. Shin, E. H. Kim , M. Kim , S. H. Baek ,J. K. Kim , T. Doeppner , A. Ali , J. Redgrave , G. Battaglia , O. N. Bae, A. Majid. LRP-1 functionalized polymersomes enhance the efficacy of carnosine in experimental stroke Sci. Rep. 2020, 10(1), 699.
X. Tian, S. Angioletti-Uberti, G Battaglia On the design of precision nanomedicines. Science Adv. 2020, 6, 4 , eaat0919
A. Joseph, C. Contini, D. Cecchin, S. Nyberg, L. Ruiz-Perez, J. Gaitzsch, G. Fullstone, X. Tian, J. Azizi, J. Preston, G. Volpe, G. Battaglia*. Chemotactic synthetic vesicles: design and applications in blood brain barrier crossing. Science Adv. 2017, 3, 8, e1700362
X. Tian*, O. Brooks, G. Battaglia*. Pericytes from Mesenchymal Stem Cells to Model for the Blood-Brain Barrier. Sci. Rep. 2017, 7, 39676
G. Fullstone, S. Nyberg, X. Tian, G. Battaglia. From the Blood to the Central Nervous System: A Nanoparticle's Journey Through the Blood–Brain Barrier by Transcytosis. Int. Rev. Neurobiol, 2016, 130, 41–72
G. Yealland, G. Battaglia, O. Bandmann, and H. Mortiboys. Rescue of mitochondrial function in parkin-mutant Fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes. Neurosci. Lett. 2016, S0304-3940(16)30474-8.
X. Tian, S. Nyberg, P. Sharp, J. Madsen, N. Daneshpour, S.P. Armes, J. Berwick, M. Azzouz, P. Shaw, N.J. Abbott and G. Battaglia*. LRP1-mediated intracellular antibody delivery to the Central Nervous System. Sci. Rep. 2015, 5, 11990
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