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I am an ICREA Professor and group leader at the Institute of Bioengineering of Catalonia, part of the Barcelona Institute of Science and Technology. I also hold an honorary professorship in Biophysical Chemistry at the University College London (UCL).Several of our activities involve the design of novel carriers to target cancer cells and/or cross the blood-brain barrier. We have developed a workflow of activities that allows the design of super-selective nanocarriers, their study in complex in vitro models and finally, the pre-clinical validation in relevant models. (See http://www.molecularbionics.org).

Existing collaborations relevant to drug delivery

Darren Hargrave, Great Ormond Street Hospital and Institute of Child Health UCL.

Prof Simona Parrinello, UCL Cancer Research UK Brain Tumour Centre of Excellence.

Prof Sebastian Brander Neurodegenerative Diseases, UCL Queen Square Institute of Neurology.

Publications relevant to drug delivery

S. Acosta-Gutiérrez, D. Matias, M. Avila-Olias, V. M. Gouveia, E. Scarpa, J. Forth, C. Contini, A. Duro-Castano, L. Rizzello, G. Battaglia A. Multiscale study of phosphorylcholine driven cellular phenotypic targeting. ACS Central Sci. 2022, 8, 7, 891–904, (front cover article).

D. M. Leite, M. Seifi, L. Ruiz-Perez, F. Nguemo, M. Plomann, J. D. Swinny, G. Battaglia. The role of syndapin-2 mediated transcytosis across the blood-brain barrier on amyloid-β accumulation in the brain. Brain Comm. 2022, 4 (1), fcac039

V. M. Gouveia, L. Rizzello, B. Vidal, C. Nunes, A. Poma, C. Lopez-Vasquez, E. Scarpa, S. Brander, A. Oliveira, J. E. Fonseca, S. Reis, G. Battaglia. Targeting activated macrophages intracellular milieu to augment anti-inflammatory drug potency. Adv. Theraup. 2022, 5 (3), 2100167 (front cover article).

A. Duro-Castano, L. Rodriguez-Arco, L. Ruiz-Perez, C. De Pace, G. Marchello, C. Noble-Jesus,G. Battaglia One-pot synthesis of oxidation-sensitive supramolecular gels and vesicles. Biomacro- molecules 2021, 22, 12, 5052–5064.

G. Pepe, C. Sfogliarini, L. Rizzello, G. Battaglia, C. Pinna, G. Rovati, P. Ciana, E. Brunialti, F. Mornata, A. Maggi, M. Locati, E. Vegeto. ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen. Biomed. & Pharmacother., 2021, 144, 112274. 

C. Noble Jesus, R. Evans, J. Forth, C. Estarellas, F. L. Gervasio, G. Battaglia. Amphiphilic Histidine-Based Oligopeptides Exhibit pH-Reversible Fibril Formation. ACS Macro Letters, 2021, 10, 984-989.

D. M. Leite, D. Matias and G. Battaglia. The Role of BAR Proteins and the Glycocalyx in Brain Endothelium Transcytosis. Cells 2020, 9(12), 2685.

X Tian, D Moreira-Leite, E Scarpa, S Nyberg, G Fullstone, J Forth, D Lourenco-Matias, A Apriceno, A Poma, A Duro-Castano, M Vuyyuru, L Harker-Kirschneck, A Saric, Z Zhang, P Xiang, B Fang, Y Tian, L Luo, L Rizzello, G Battaglia. On the shuttling across the blood-brain barrier via tubules formation: mechanism and cargo avidity bias. Science Adv. 2020, 6 (48), eabc4397B.

Sola-Barrado, D. Moreira-Leite, E. Scarpa, A. Duro-Castano, G. Battaglia. Combinatorial Intracellular Delivery Screening of Anticancer Drugs. Mol. Pharmac. 2020, 10.1021/acs.molpharmaceut.0c00791A.

Duro-Castano D. Moreira-Leite, J. Forth, Y. Deng D. Matias , C. Noble-Jesus G. Battaglia. Designing peptide nanoparticles for efficient brain delivery. Adv. Drug Deliv. Rev. 2020, 160, 52-77.

M. Liu, A. Apriceno, M. Sipin, E. Scarpa,L. Rodriguez-Arco, A. Poma, G. Marchello,G. Battaglia, S. Angioletti-Uberti*. Combinatorial entropy behaviour leads to range selective binding in ligand receptor interactions. Nature Comm. 2020 11, 4836E.

S. Kim , D. Kim , S. Nyberg , A. Poma , D. Cecchin , S. Jain, K. A. Kim , Y. J. Shin, E. H. Kim , M. Kim , S. H. Baek ,J. K. Kim , T. Doeppner , A. Ali , J. Redgrave , G. Battaglia , O. N. Bae, A. Majid. LRP-1 functionalized polymersomes enhance the efficacy of carnosine in experimental stroke. Sci. Rep. 2020, 10(1), 699.

X. Tian, S. Angioletti-Uberti, G Battaglia. On the design of precision nanomedicines. Science Adv. 2020, 6, 4 , eaat0919.

A. Joseph, C. Contini, D. Cecchin, S. Nyberg, L. Ruiz-Perez, J. Gaitzsch, G. Fullstone, X. Tian, J. Azizi, J. Preston, G. Volpe, G. Battaglia. Chemotactic synthetic vesicles: design and applications in blood brain barrier crossing. Science Adv. 2017, 3, 8, e1700362.

X. Tian*, O. Brooks, G. Battaglia. Pericytes from Mesenchymal Stem Cells to Model for the Blood-Brain Barrier. Sci. Rep. 2017, 7, 39676.