George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, USA
I am Head of the Ultrasound Biophysics and Bioengineering Lab. Our research investigates the therapeutic applications of ultrasound with an emphasis on brain cancer, and central nervous system disease and disorders. Our research is focused on understanding the biological effects of ultrasound and acoustically induced microbubble oscillations (acoustic cavitation) and using them to study complex biological systems, such as the neurovascular network and the tumor microenvironment, with the goal of developing novel therapies for the treatment of cancer and central nervous system diseases and disorders.
Specific areas of our research include biomedical ultrasonics, linear and nonlinear acoustics, sound propagation in complex media (brain/skull), microbubble dynamics (acoustic cavitation) and control, and image guided therapy. Our lab is particularly active in the field of cancer research, where we conduct fundamental investigations on ultrasound and microbubble-meditated mass transport in brain tumors and develop computational tools to support the more rational design of focused-ultrasound-based treatment of brain cancer.
Existing collaborations relevant to drug delivery
Publications relevant to drug delivery
S.J.Schoen Jr, Z.Zhao, A.Alva, C.Huang, S.Chen, and C.D.Arvanitis “Morphological Reconstruction Improves Microvessel Mapping in Super-Resolution Ultrasound” IEEE Transactions on Ultrasonics, Ferroelectrics, And Frequency Control (In Press) [arXiv]
S.J.Schoen Jr and C.D.Arvanitis “Heterogeneous Angular Spectrum Method for Trans-skull Imaging and Focusing” Journal of the Acoustical Society of America 148(4) EL333-EL339, 2020. DOI: 10.1121/10.0002095
S.J.Schoen Jr and C.D.Arvanitis “Heterogeneous Angular Spectrum Method for Trans-skull Imaging and Focusing” IEEE Transactions on Medical Imaging 39(5) 1605-1614, 2020. DOI: 10.1109/TMI.2019.2953872
C.D.Arvanitis, G.B.Ferraro, and R.K.Jain “The blood-brain barrier and blood–tumor barrier in brain tumors and metastases” Nature Reviews Cancer 20 26-41 2020. DOI: 10.1038/s41568-019-0205-x
A.Patel, S.J.Schoen Jr, and C.D.Arvanitis, “Closed-loop spatial and temporal control of cavitation activity with passive acoustic mapping” IEEE Transaction on Biomedical Engineering 66(7) 2022 – 2031, 2019.
C.D.Arvanitis, V.Askoxylakis, Y.Guo, M.Datta, J.Kloepper, G.B.Ferraro, M.O.Bernabeu, D.Fukumura, N.McDannold, and R.K.Jain, “Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood–tumor barrier disruption”, Proceedings of the National Academy of Sciences, 115(37), E8717–E8726, 2018.
V.Askoxylakis, C.D.Arvanitis, , C.Wong, G.B.Ferraro, and R.K.Jain “Emerging Strategies for Delivering Antiangiogenic Therapies to Primary and Metastatic Brain Tumors” Advanced Drug Delivery Reviews, 119, pp 159-174, 2017
C.D.Arvanitis, N.McDannold, and G.T.Clement “Fast Passive Acoustic Mapping with Angular Spectrum Approach” IEEE T. Med. Imaging, 36(4), 983-993, 2017
K.Zervantonakis and C.D.Arvanitis “Controlled Drug Release and Chemotherapy Response in a Novel Acoustofluidic 3D Tumor Platform” Small, 12(19) 2616–2626, 2016.
C.D.Arvanitis, N.Vykhodtseva, F.Jolesz, M.S.Livingstone and N.McDannold “Cavitation Enhanced Non-Thermal Ablation in Deep Brain Targets: Feasibility in a Large Animal Model” Journal of Neurosurgery 124(5), pp1450-1459, 2016.
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