Professor of Polymer Therapeutics
University of Nottingham, UK
School of Pharmacy
I am Professor of Polymer Therapeutics at the School of Pharmacy in Nottingham. The main areas of our research are the synthesis and characterisation of bioresponsive materials and externally-activated biosensing and release polymers. These polymers can be triggered to release signals or therapeutic cargoes by heat, light, pH, redox and enzymatic activity. We aim to deliver cancer drugs and / or biological therapeutics to enhance safety, tolerability and efficacy of treatments.
Existing collaborations relevant to drug delivery
Current projects with Dr Ruman Rahman (Nottingham) on polymer pro-drugs for local delivery (post-surgery) to brain tissue and prior work with Professor David Walker (Nottingham) and Dr Martin Garnett (Nottingham) on 3D spheroid co-cultures to evaluate drug delivery systems.
Publications relevant to drug delivery
Pearce, A. K.; Anane-Adjei, A. B.; Cavanagh, R. J.; Monteiro, P. F.; Bennett, T.; Clarke, P.; Ritchie, A.; Alexander, M. R.; Grabowska, A. M.; and Alexander, C. Effects of Polymer 3D Architecture, Size and Chemistry on Biodistribution and Drug Delivery In Vitro and in Orthotopic Triple Negative Breast Cancer Models. Advanced Healthcare Materials 2020, 200892.
Taresco, V.; Abelha, T. F.; Cavanagh, R. J.; Vasey, C. E.; Anane-Adjei, A. B.; Pearce, A. K.; Monteiro, P. F.; Spriggs, K. A.; Clarke, P.; Ritchie, A.; Martin, S. G.; Rahman, R.; Grabowska, A. M.; Ashford, M. B. and Alexander, C. Functionalized block co-polymer pro-drug nanoparticles with anti-cancer efficacy in 3D spheroids and in an orthotopic triple negative breast cancer model. Advanced Therapeutics 2020, 2000103. https://doi.org/10.1002/adtp.202000103
Greco, C.; Taresco, V.; Pearce, A. K.; Vasey, C. E.; Smith, S.; Rahman, R.; Alexander, C.; Cavanagh, R. J.; Musumeci, F.; Schenone, S. Development of Pyrazolo[3,4-d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme. ACS Medicinal Chemistry Letters, 2020, 11(5), 657–663.
Monteiro, P. F.; Gulfam, M.; Monteiro, C. J.; Travanut, A.; Abelha, T. F.; Pearce, A. K.; Jerôme, C.; Grabowska, A. M.; Clarke, P. A.; Collins, H. M.; Heery, D. M.; Gershkovich, P and Alexander, C. Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer. Journal of Controlled Release 2020, 323, 549-564.
Hsu, W-H.; Sanchez-Gomez, P.; Gomez-Ibarlucea, E.; Ivanov, D.; Rahman, R.; Grabowska, A. M.; Csaba, N.; Alexander, C. and Garcia-Fuentes, M. Structure-optimized interpolymer polyphosphazene complexes for effective gene delivery against glioblastoma. Advanced Therapeutics 2019, 2(3), 1800126.
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