King's College, London, UK
Drug Delivery & Nanomedicine
I am the chair of Drug Delivery & Nanomedicine in the School of Cancer and Pharmaceutical Sciences at King's College London. I lead a research team focusing on the design and development of novel nanoscale delivery systems specifically for drug, gene, vaccine and radionuclide delivery for therapeutic or diagnostic applications, particularly in the field of cancer studies and brain drug delivery. I have extensive experience with dendrimers, liposomes, quantum dots, polymers, viral vectors, chemically functionalised carbon nanotubes and graphene oxide. I have developed a number of injectable nanocarriers capable of crossing the blood-brain barrier and targeting glioblastoma for cancer therapy in mouse models, and have also designed nanocarriers capable of translocating to the brain after intranasal administration exploiting the nose-to-brain delivery route for treatment of neurodegenerative diseases.
Existing collaborations relevant to drug delivery
Prof. A. Bianco, CNRS, France and Prof. M. Prato, University of Trieste, Italy (Chemical functionalisation of carbon nanotubes)
Dr G. Tobias, ICMAB-CSIC, Barcelona, Spain (Carbon nanotube growth and filling)
Dr Jane Sosabowski, Queen Mary's School of Medicine and Dentistry, UK
Prof. NJ Abbott and Dr J Preston, KCL (Blood Brain Barrier)
Dr Belén Ballesteros, The Catalan Institute of Nanotechnology, Barcelona (advanced electron microscopy)
Dr Rafael Torres Martin De Rosales, Cancer Imaging, KCL.
Publications relevant to drug delivery
P M Costa, JT-W Wang, J-F Morfin, T Khanum, W To, JK Sosabowski, E Tóth, KT Al-Jamal. (2018) Functionalised carbon nanotubes enhance brain delivery of amyloid-targeting Pittsburgh Compound B (PiB)-derived ligands. Nanotheranostics. 2(2):168-183.
PM Costa, M Bourgognon, JT-W Wang, KT Al-Jamal KT. (2016) Functionalised carbon nanotubes: From intracellular uptake and cell-related toxicity to systemic brain delivery. Journal of Controlled Release. 241:200-219
H Kafa, J T-W Wang, N Rubio, R Klippstein, PM Costa, HA Hassan, JK Sosabowski, SS Bansal, JE Preston, NJ Abbott and KT Al-Jamal. (2016) Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood-brain barrier in vitro and in vivo. Journal of Controlled Release. 225:217-229.
JT-W Wang, N Rubio, H Kafa, E Venturelli, C Fabbro, C Ménard-Moyon, T Da Ros, JK Sosabowski, M Prato, A Bianco, F Festy, JE Preston, K Kostarelos and KT Al-Jamal. (2016) Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses. Journal of Controlled Release. 224:22-32.
JT-W Wang and KT Al-Jamal. (2015) Functionalized carbon nanotubes: revolution in brain delivery. Nanomedicine (Lond). 10(17):2639-2642.
H Kafa, JT-W Wang, N Rubio, K Venner, G Anderson, E Pach, B Ballesteros, JE Preston, NJ Abbott, KT Al-Jamal. (2015) The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo. Biomaterials. 53:437-452.
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