University of Aberdeen, UK
My research in cancer therapy centres on the multiscale modelling of drug delivery to solid tumour. Numerical platforms are established to predict the time-course and spatial-distribution of drug accumulation in different tissue compartments and cell killing. It is coupled with tumour morphological and biological properties extracted from medical images to mimic the intratumoural environment. The output could provide suggestions to the design of drug-delivery-systems, and the strategies of routine chemotherapy and advanced therapies using, i.e. ultrasound and nanoparticles.
Existing collaborations relevant to drug delivery
(1) Radiologists in medical imaging;
(2) Scientists and engineers in drug delivery system, such as nanoparticle, wafer, liposome, etc.
Publications relevant to drug delivery
Zhan, Wenbo. Convection Enhanced Delivery of Anti-angiogenic and Cytotoxic Agents in Combination Therapy against Brain Tumour. European Journal of Pharmaceutical Sciences, 2020 (141): 105094.
Zhan, Wenbo. Effects of Focused-Ultrasound-and-Microbubble-Induced Blood-Brain Barrier Disruption on Drug Transport under Liposome-Mediated Delivery in Brain Tumour: A Pilot Numerical Simulation Study. Pharmaceutics, 2020, 12(1): 69.
Wenbo Zhan, Daniele Dini, Ferdinando Rodriguez y Baena. Effect of Tissue Permeability and Drug Diffusion Anisotropy on Convection Enhanced Delivery. Drug Delivery, 2019, 26 (1), 773-781.
Wenbo Zhan, Wladyslaw Gedroyc, Xiao Yun Xu. Towards A Multiphysics Modelling Framework for Thermosensitive Liposomal Drug Delivery to Solid Tumour Combined with Focused Ultrasound Hyperthermia. Biophysics Reports, 2019, 5 (1): 43-59.
Wenbo Zhan, Chenlu Lei, Pooya Davoodi, et al. Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration into Brain Tissue. Journal of Pharmaceutical Sciences, 2019, 108 (5), 1736-1745. (Featured on Journal Website)
Wenbo Zhan. Delivery of Liposome Encapsulated Temozolomide to Brain Tumour: Understanding the Drug Transport for Optimisation. International Journal of Pharmaceutics, 2019, 557: 280-292.
Wenbo Zhan, Moath Alamer, Xiao Yun Xu. Computational Modelling of Drug Delivery to Solid Tumour: Understanding the Interplay between Chemotherapeutics and Biological System for Optimised Delivery System. Advanced Drug Delivery Reviews, 2018, 132: 81-103.
Chi-Hwa Wang, Xiao Yun Xu, Wenbo Zhan, et al. 3D-Bioprinting and Micro-/Nano-Technology: Emerging Technologies in Biomedical Sciences. Advanced Drug Delivery Reviews, 2018, 132: 1-2.
Wenbo Zhan, Chi-Hwa Wang. Convection Enhanced Delivery of Liposome Encapsulated Doxorubicin for Brain Tumour Therapy. Journal of Controlled Release, 2018, 285: 212-229.
Wenbo Zhan, Chi-Hwa Wang. Convection Enhanced Delivery of Chemotherapeutic Drugs into Brain Tumour. Journal of Controlled Release, 2018, 271:74-87.
Wenbo Zhan, Wladyslaw Gedroyc, Xiao Yun Xu. The Effect of Tumour Size on Drug Transport and Uptake in 3-D Tumour Models Reconstructed from Magnetic Resonance Images. PLoS One, 2017, 12.2: e0172276.
Wenbo Zhan, Davis Yohanes Arifin, Timothy KY Lee, et al. Mathematical Modelling of Convection Enhanced Delivery of Carmustine and Paclitaxel for Brain Tumour Therapy. Pharmaceutical Research, 2017, 34(4): 860-873. (Cover Page)
Yilong Fu, Lai-Chun Ong, Sudhir H Ranganath, et al. A Dual Tracer 18F-FCH/18F-FDG PET Imaging of an Orthotopic Brain Tumor Xenograft Model. PLoS One, 2016, 11.2: e0148123.
Wenbo Zhan, Wladyslaw Gedroyc, Xiao Yun Xu. Effect of Heterogeneous Microvasculature Distribution on Drug Delivery to Solid Tumour. Journal of Physics: D Applied Physics. 2014, 47: 475401.
Wenbo Zhan, Wladyslaw Gedroyc, Xiao Yun Xu. Mathematical Modelling of Drug Transport and Uptake in a Realistic Model of Solid Tumour. Protein and Peptide Letters, 2014, 21(11): 1146-1156.
Wenbo Zhan, Xiao Yun Xu. A Mathematical Model for Thermosensitive Liposomal Delivery of Doxorubicin to Solid tumour. Journal of Drug Delivery, 2013: 172529.
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