Medical College of Wisconsin, USA
My team has developed advanced MRI methods to aid in the evaluation of treatment response in patients with brain tumors. While most of our work has been in the adult population, recent work includes pediatric patients.
Existing collaborations relevant to drug delivery
Publications relevant to drug delivery
Schmainda KM, Prah MA, Rand SD, Liu Y, Logan B, Muzi M, Rane SD, Da X, Yen YF, Kalpathy-Cramer J, Chenevert TL, Hoff B, Ross B, Cao Y, Aryal MP, Erickson B, Korfiatis, Dondlinger T, P, Bell L, Hu L, Kinahan P, Quarles CC. "Multi-site concordance of DSC-MRI analysis for brain tumors: Results of a NCI Quantitative Imaging Network DSC-MRI Collaborative Project". Am J Neurorad (In Press).
Prah MA, Al-Gizawiy MM, Mueller WM, Cochran EJ, Hoffmann RG, Connelly JM, Schmainda KM. Spatial discrimination of glioblastoma and treatment effect with histologically-validated perfusion and diffusion magnetic resonance imaging metrics. J Neurooncol, 136:13-21 (2018).
Prah MA, Stufflebeam SM, Paulson ES, Kalpathy-Cramer J, Gerstner ER, Batchelor TT, Barboriak DP, Rosen BR, Schmainda KM. "Repeatability of standardized and normalized relative CBV in patients with newly diagnosed glioblastoma." Am J Neuroradiol 36(9):1654-1661 (2015). PMID: 26066626.
Schmainda KM, Zhang Z, Prah M, Snyder BS, Gilbert MR, Sorensen AG, Barboriak DP, Boxerman JL. "Dynamic susceptibility contrast MRI measures of relative cerebral blood volume as a prognostic marker for overall survival in recurrent glioblastoma: results from the ACRIN 6677/RTOG 0625 multicenter trial." Neuro Oncol 17(8):1148-1156 (2015).
Schmainda KM, Prah M, Connelly J, Rand SD, Hoffman RG, Mueller W, Malkin MG. "Dynamic-susceptibility contrast agent MRI measures of relative cerebral blood volume predict response to bevacizumab in recurrent high-grade glioma." Neuro-Oncology 16(6):880-888 (2014). PMID: 24431219.
Schmainda KM. "Diffusion-weighted MRI as a biomarker for treatment response in glioma." CNS Oncol 1(2):169-180 (2013). PMID: 23936625.
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