Sarmento, Bruno

Principal Investigator

University of Porto, Portugal

Nanomedicines and Translational Drug Delivery

My research is focused on the development of functionalized nanomedicines for biomedical applications, with particular interest in brain cancer and neurological disorders. I have also specialized in BBB engineering models to validate functionalized nanomedicines and to perform in vitro/in vivo correlation. 

Existing collaborations relevant to drug delivery

N/A

Publications relevant to drug delivery

Castro F, Martins C, Silveira MJ, et al. Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments, Advanced Drug Delivery Reviews, in press

Moura R, Pacheco C Pêgo AP, et al. Lipid nanocapsules to enhance drug bioavailability to the central nervous system, Journal of Controlled Release, 322, 390-400, 2020

Pacheco C, Sousa F, Sarmento B. Chitosan-based nanomedicine for brain delivery: Where are we heading? Reactive and Functional Polymers 146, 104430, 2020

Cayero-Otero M, Gomes MJ, Martins C, et al. In vivo biodistribution of venlafaxine-PLGA nanoparticles for brain delivery: Plain vs functionalized nanoparticles, Expert Opinion on Drug Delivery, 16, 1413-1429, 2019

Sousa F, Dhaliwal H, Gattacceca F, et al. Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles, Journal of Controlled Release, 309, 37-47, 2019

Martins C, Araújo F, Gomes MJ, et al. Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy, European Journal of Pharmaceuticals and Biopharmaceuticals, 138, 111-124, 2019

Moura R, Martins C, Pinto S, et al. Blood-Brain Barrier receptors and transporters: An insight on their function and how to exploit them through nanotechnology, Expert Opinion on Drug Delivery, 16, 271-285, 2019

Fernandes C, Pinto M, Martins C, et al. Development of a PEGylated-based platform for efficient delivery of dietary antioxidants across the blood–brain barrier, Bioconjugate Chemistry, 29, 1677-1689, 2018

Moura R, Almeida A, Sarmento B. The role of non-endothelial cells on the penetration of nanoparticles through the blood brain barrier, Progress in Neurobiology, 159, 39-49, 2017


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