Assistant Professor of Molecular Neuro-Oncology
University of Nottingham, UK
My research group has developed a localised drug delivery system, in which a biodegradable polymer (PLGA/PEG) is applied around the tumour cavity wall at neurosurgical resection. The polymer forms a paste at room temperature, which solidifies next to the surgical cavity wall at body temperature. This gives spatial control over dose delivery, extending the length of time infiltrative tumour cells are exposed to the drug.
My expertise is in:
- Local biomaterial-based drug delivery systems for intracranial tumours
- 3D brain tumour models for drug screening
- Bio-instructive nanotherapeutics
- HDAC inhibitors
- Brain intra-tumour heterogeneity.
Existing collaborations relevant to drug delivery
Prof. Henry Brem and Dr. Betty Tyler (Johns Hopkins Medical School) – Evaluation of polymer-based chemotherapy delivery using neurosurgical orthotopic high grade glioma models.
Publications relevant to drug delivery
Nailor A, Walker DA….Smith S, Rahman R, Kilday JP. Highlights of Children with Cancer UK’s workshop on drug delivery in paediatric brain tumours. Ecancermedicine (IF 1.0) Mar 31; 10:630. doi: 10.3332/ecancer.2016.630 (2016).
Rahman R. Biomaterial-based local drug delivery to brain tumors. Therapeutic Delivery 5(12): 1243-1245 (2014).
Smith SJ, Rahman CV, Clarke PA, Ritchie AA, Gould TW, Ward JH, Shakesheff KM, Grundy RG, Rahman R. Surgical delivery of drug-releasing poly(lactic-co-glycolic acid) / poly(ethylene glycol) paste with in vivo effects against glioblastoma. Annals of Royal College of Surgeons England 96: 495-501 (2014).
Rahman CV, Smith SJ, Morgan PS, Langmack KA, Clarke PA, Ritchie AA, Macarthur DC, Rose FR, Shakesheff KM, Grundy RG, Rahman R. Adjuvant chemotherapy for brain tumours delivered via a novel intra-cavity mouldable polymer matrix. PLoS One 8(10): e77435 (2013).
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