Pilkington, Geoff


University of Portsmouth, UK

Brain Tumour Research Centre

Development of state-of-the-art 3D all-human models (2D and 3D, static and dynamic) in vitro models of the blood-brain barrier for use in drug delivery through transient opening mechanism and nanoparticle delivery. Currently working on models for tumour spread (vascular and CSF/leptomeningeal) in medulloblastoma as well as on 3D multicellular (neoplastic and non-neoplastic) models for drug testing in brain tumour. 

Existing collaborations relevant to drug delivery

University of Central Lancashire, UK

University of Bergen, Norway

Trinity College, Cork, Ireland

University of Cardiff, UK

University of Oxford, UK

Publications relevant to drug delivery

Maherally, Z; Fillmore, HL; Tan, SL; Tan, SF; Jassam, SA; Quack, FI; Hatherell, KE; and Pilkington, GJ.  Real-time acquisition of trans-endothelial electrical resistance in an all-human, in vitro, 3-dimensional, blood–brain barrier model exemplifies tight-junction integrity. FASEB Journal Published Online:7 Sep 2017https://doi.org/10.1096/fj.201700162R

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