University of Nottingham, UK
New endogenous-inspired nanoparticle designs for metastatic cancer, including: synthesis, characterisation, and formulation of the pro-drug Niclosamide Stearate (NSNP); NSNP testing in vitro for cell-uptake and cytotoxicity in glioblastoma, breast and prostate cancers; and in vivo preclinical studies showing encouraging results in flank and metastatic tumours with growth delays and extended lifetimes for the NSNP-treated animals. Also includes PET-imageable nanoparticles which, in combination with the NSNPs, forms a suite of diagnostic and therapeutic "Individualised nano-medicines" for cancer.
Existing collaborations relevant to drug delivery
I have started discussions with David Walker and Ruman Raman in the CBTRC (Nottingham) regarding designing, making, and testing administration-route-specific formulations of brain tumor drugs for intra-venous-arterial, intrathecal and interstitial administration.
Publications relevant to drug delivery
Hervella P, Parra-Ortiz E, Needham D (2016). Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core forumation. European Journal of Pharmaceutics and Biopharmaceutics, 2016, 102, 64-76.
Needham D, Arslanagic A, Glud K, Hervella P, Karimi L, Høilund-Carlsen PF, Kinoshita K, Mollenhauer J, Parra E, Utoft A, Walke P (2016). Bottom Up Design of Nanoparticles (to eventually treat cancer): “Put the drug in the Cancer’s food”, in review, a “Special issue of J. Drug Targeting in honour of Pieter Cullis, Life-time Achievement Award for 2016” 24(9), 836-856.
Needham D (2016) “Bringing Research to Clinical Application: Lessons from Thermodox - A Thermal Sensitive Liposome for Treatment of Cancer”, invited chapter, In " Drug Delivery and Targeting: Fundamentals, Applications and Future Directions” Editors, HILLERY, AM, SWARBRICK J, PARK, K, CRC Press, Boca Raton, 523-583.
Zagar TM, Vujaskovic Z, Formenti S, Rugo H, Muggia F, O'Connor B, Myerson R, Stauffer P, Hsu IC, Diederich C, Straube W, Boico A, Craciunescu O, Maccarini P, Needham D, Borys N, Blackwell KL, Dewhirst MW (2014) Two phase I dose escalation/ pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local-regionally recurrent breast cancer. Int. J Hyperthermia 30(5), 285-294.
Olsen BB, Thisgaard H, Vogel S, Thomassen M, Kruse TA, Needham D, Mollenhauer J, Høilund-Carlsen PF (2013) Novel Radioisotope-Based Nanomedical Approaches. European Journal of Nanomedicine 5(4) 181–193, ISSN (Online) 1662-596X, ISSN (Print) 1662-5986, DOI: 10.1515/ejnm-2013-0025
Ryan M Davis, Benjamin L Viglianti, Pavel Yarmolenko, Paul Stauffer, Ji-Young Park, David Needham, Mark W Dewhirst. (2013). A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. Int. J. Hyperthermia, 2013; 29(6): 569–581.
Needham D, Park JY, Wright AM, Tong J (2013). Materials Characterization of the Low Temperature Sensitive Liposome (LTSL): Effects of Lipid Composition (Lysolipid and DSPE-PEG2000) on the Thermal Transition and Release of Doxorubicin. Faraday Discussions 161: Lipids and Membrane Biophysics, 515-534 and 563-589.
Needham D (2013) Reverse Engineering the Low Temperature Sensitive Liposome (LTSL). In "Biomaterials for Cancer Therapeutics. Diagnosis, prevention and therapy”, Edited by Kinam Park, Woodhead Publishing Series in Biomaterials No. 66, Chapter 12. ISBN 978 0 85709 664 7.
Manzoor AA, Lindner LH, Landon CD, Park JY, Simnick AJ, Dreher MR, Das S, Hanna G, Park W, Koning GA, ten Hagen TL, Needham D, Dewhirst MW (2012). Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors, Cancer Research 2012 Nov 1;72(21):5566-5575.
Needham D, Dewhirst MW (2012) Materials Science and Engineering of the Low Temperature Sensitive Liposome (LTSL): Composition-Structure-Property Relationships that Underlie its Design and Performance, (Chapter 2). In “Smart Materials for Drug Delivery”, Carmen Alvarez-Lorenzo and Angel Concheiro Eds, Royal Society of Chemistry, Publishing.
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