Farrer, Nicola

Synthetic and Analytical Chemist

University of Oxford, UK

I am primarily a synthetic and analytical chemist with a background in Natural Sciences (Physics, Biochemistry, Chemistry). My multi-disciplinary research involves the development of metal-based systems that respond to external stimuli (light, ultrasound) for application in the imaging and treatment of cancer. During postdoctoral work I developed photo-activatable anti-cancer platinum prodrugs. As a Wellcome Trust Career Re-Entry Fellow I am currently developing novel multimodal anti-cancer complexes and investigating their encapsulation and delivery using ultrasound.   

Existing collaborations relevant to drug delivery

Department of Chemistry (Oxford) –  with Dr. Akane Kawamura (epigenetics) and Prof. Stephen Faulkner (imaging):  synthesis of multimodal anti-cancer prodrugs for imaging and therapy.

Institute of Biomedical Engineering (Oxford) – with Profs. Eleanor Stride, Constantin Coussios and Robert Carlisle: acoustic drug delivery.

Publications relevant to drug delivery

Y. Zhao, N. J. Farrer, H. Li, J. S. Butler, R. J. McQuitty, A. Habtemariam, F. Wang, P. J. Sadler, "De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex", Angew. Chem. Int. Ed., 2013, 52, 13633 – 13637.

Y. Zhao, J. A. Woods, N. J. Farrer, K. S. Robinson, J. Pracharova, J. Kasparkova, O. Novakova, H. Li, L. Salassa, A. M. Pizarro, G. J. Clarkson, L. Song, V. Brabec, P. J. Sadler, " Diazido Mixed-Amine Platinum(IV) Anticancer Complexes Activatable by Visible-Light Form Novel DNA Adducts" Chem Eur. J., 2013, 19, 9578 – 9591. 

J. S. Butler, J. A. Woods, N. J. Farrer, M. E. Newton, P. J. Sadler "Tryptophan Switch for a photoactivated platinum anticancer complex " J. Am. Chem. Soc., 2012, 134, 16508– 16511.

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