De Vleeschouwer, Steven

Staff neurosurgeon / Professor

University Hospitals Leuven, KU Leuven, Belgium

Experimental neurosurgery and neuroanatomy

Preclinical and conceptual research in nose-to-brain delivery of innovative therapeutics including formulated RNAi substances. Preclinical research in consortium for development of multichannel microcatheter for CED in brain tumors including brainstem locations.

Existing collaborations relevant to drug delivery

Lab of toxicology, ULB.

Brussels Lab of Biopharmacology, ULB.

Brussels IMEC, Leuven, Belgium.

Publications relevant to drug delivery

Van Woensel M., Mathivet T., Wauthoz N., Rosière R., Garg A., Agostinis P., Mathieu V., Kiss R., Lefranc F., Boon L., Belmans J., Van Gool S., Gerhardt H., Amighi K., De Vleeschouwer S. (2017).  Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy. Scientific Reports, 7(1), 10.1038/s41598-017-01279-1, 1217.

Van Woensel M., Wauthoz N., Rosière R., Mathieu V., Kiss R., Lefranc F., Steelant B., Dilissen E., Van Gool S., Mathivet T., Gerhardt H., Amighi K., De Vleeschouwer S. (2016). Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration. Journal of Controlled Release, 227, 10.1016/j.jconrel.2016.02.032. 

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