Cima, Michael

Professor of Engineering

Massachusetts Institute of Technology, USA

Koch Institute of Integrative Cancer Research

I lead a research lab focusing on developing medical devices for single compartment drug delivery with a history of clinical translation. I am currently developing a minimally invasive device for chronic fluid infusion and electrical interfacing with discrete deep-brain structures. I have experience as a founder of four startup companies and of consulting for several pharmaceutical companies.

Existing collaborations relevant to drug delivery

Bob Langer, Ann Graybiel (MIT) – Development of neural implant for drug delivery and chemical sensing.

Publications relevant to drug delivery

Dagdeviren, C, Ramadi, K, Joe, P, Spencer, K, Schwerdt, HN, Shimazu, H, Delcasso, S, Amemori, K, Lopez, CN, Ann, M, Cima, MJ & Langer, R. Regulation of Brain Activity by a Minimally Invasive Drug Delivery System. Sci. Trans. Med., Accepted (2017).

Spencer, KC, Sy, JC, Ramadi, KB, Graybiel, AM, Langer, R. & Cima, MJ. Characterization of mechanically matched hydrogel coatings to improve the biocompatibility of neural implants. Sci. Rep. 7, 1952 (2017).

Upadhyay, UM, Tyler, B, Patta, Y, Wicks R, Spencer, K, Scott, A, Masi, B, Hwang, L, Grossman, R, Cima, M, Brem, H, Langer, R. Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain. Proc Natl Acad Sci. 2013; 11(45):16071-16076. DOI: 10.1073/pnas.1313420110.


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