Imperial College, London, UK
Department of Bioengineering
Noninvasive and localised drug delivery across the blood-brain barrier using ultrasound and microbubbles. I have over 12 journal publications on this topic and continue to develop different aspects of this technology.
Existing collaborations relevant to drug delivery
I am currently working on three collaborative projects related to delivering drugs in the brain for paediatric brain cancer, glioblastoma multiforme, and Alzheimer’s disease.
Publications relevant to drug delivery
Heymans SV, Martindale CF, Suler A, Pouliopoulos AN, Dickinson RJ, Choi JJ. Simultaneous Ultrasound Therapy and Monitoring of Microbubble-Seeded Acoustic Cavitation Using a Single-Element Transducer. IEEE Trans Ultrason Ferroelectr Freq Control. 64(8):1234-1244. 2017
Zhang C, Yao ZC, Ding Q, Choi JJ, Ahmad Z, Chang MW, Li JS. Tri-Needle Coaxial Electrospray Engineering of Magnetic Polymer Yolk-Shell Particles Possessing Dual-Imaging Modality, Multiagent Compartments, and Trigger Release Potential. ACS Appl Mater Interfaces. 28;9(25):21485-21495. 2017
Pouliopoulos AN, Li C, Tinguely M, Garbin V, Tang MX, Choi JJ. Rapid short-pulse sequences enhance the spatiotemporal uniformity of acoustically driven microbubble activity during flow conditions. J Acoust Soc Am. 140;2469. 2016 Link
Pouliopoulos AN, Choi JJ. Superharmonic microbubble Doppler effect in ultrasound therapy. Phys Med Biol. 61(16):6154-6171. 2016
Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R, Choi JJ. Enhancement of Non-invasive Trans-membrane Drug Delivery Using Ultrasound and Microbubbles during Physiologically Relevant Flow. Ultrasound Med Biol. 41(9):2435-2448. 2015. Link
Coviello C, Kozick R, Choi J, Gyöngy M, Jensen C, Smith PP, Coussios CC. Passive acoustic mapping utilizing optimal beamforming in ultrasound therapy monitoring. J Acoust Soc Am. 137(5):2573. 2015.
Pouliopoulos A, Bonaccorsi S, Choi JJ. Exploiting flow to control the in vitro spatiotemporal distribution of microbubble-seeded acoustic cavitation activity in ultrasound therapy. Phys Med Biol. 59(22):6941-6957. 2014. Link
Choi JJ, Carlisle RC, Coviello C, Seymour L, Coussios CC. Non-invasive and real-time passive acoustic mapping of ultrasound-mediated drug delivery. Phys Med Biol. 59(17):4861-4877. 2014.
Graham S, Carlisle R, Choi J, Stevenson M, Shah A, Myers R, Fisher K, Peregrino MB, Seymour L, Coussios CC. Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes. J Control Release. 178:101-107. 2014.
Carlisle R, Choi J, Bazan-Peregrino M, Laga R, Subr V, Kostka L, Ulbrich K, Coussios CC, Seymour LW. Enhanced Tumor Uptake and Penetration of Virotherapy Using Polymer Stealthing and Focused Ultrasound. J Natl Cancer Inst. 105(22):1701-1710. 2013.
Bazan-Peregrino M, Rifai B, Carlisle RC, Choi J, Arvanitis CD, Seymour LW, Coussios CC. Cavitation-enhanced delivery of a replicating oncolytic adenovirus to tumors using focused ultrasound. J Control Release. 169(1-2):40-47. 2013
Choi JJ, Coussios CC. Spatiotemporal evolution of cavitation dynamics exhibited by flowing microbubbles during ultrasound exposure. J Acoust Soc Am. 132(5):3538-3549. 2012.
Baseri B, Choi JJ, Deffieux T, Samiotaki G, Tung YS, Konofagou EE. Activation of downstream signaling molecules following localized delivery of brain-derived neurotrophic factors to murine brain using focused ultrasound and microbubbles. Phys Med Biol. 57(7):N65-81. 2012.
Konofagou EE, Tung YS, Choi JJ, Deffieux T, Baseri B, Vlachos F. Ultrasound-induced blood-brain barrier opening. Curr Pharm Biotechnol. 13(7):1332-1345. 2012.
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