University of Nottingham, UK
More than 25 years' experience in the cancer pharmacology and drug discovery fields investigating antitumour activity and mechanisms of action of NCEs, natural products and novel formulations of test agents to enhance and target drug delivery. Of particular interest are self-assembling small molecule hydrogelators and apoferritin-encapsulated formulations for treatment of intractable, drug-resistant cancers.
Existing collaborations relevant to drug delivery
Professor Neil Thomas (University of Nottingham), Dr. Lyudmila Turyanska (University of Lincoln), Dr. Geoff Wells (UCL): Apoferritin-encapsulated imidazotetrazine and benzothiazole analogues.
Dr. Beth Coyle, Dr. Pavel Gershkovic, Dr. Jeni Luckett (University of Nottingham), Dr. Ali Bieneman, Prof. Stephen Lowis, Dr. Will Singleton (University of Bristol): Development of N3-Propargyl imidazotetranine formulations for Convection Enhanced Delivery to the brain.
Publications relevant to drug delivery
F Citossi, T Smith, L-J Bong, J Segal, P Gershkovich, MJ Stocks, TD Bradshaw, B Kellam, M Marlow. Self-assembling benzothiazole-based gelators: a mechanistic understanding of in vitro bioactivation and gelation. Molecular Pharmaceutics 2018, in press.
K.J. Skilling, B. Kellam, M. Ashford, T.D. Bradshaw and M. Marlow. Developing a self-healing supramolecular nucleoside hydrogel. Soft Matter 2016, 12, 8950-8957; DOI: 10.1039/C6SM01779G.
David Cousin, Jihong Zhang, Marc G. Hummersone, Charles S. Matthews, Mark Frigerio, Tracey D. Bradshaw, and Malcolm F. G. Stevens. Antitumor Imidazo[5,1-d]-1,2,3,5-tetrazines: Compounds Modified at the 3-Position overcome Resistance in Human Glioblastoma Cell Lines. MedChemComm, 2016, 7, 2332-2343; DOI: 10.1039/C6MD00384B
EL Stone, F Citossi, R Singh, B Kaur, M Gaskell, P B Farmer, A Monks, C Hose, MFG Stevens, C-O Leong, M Stocks, B Kellam, M Marlow and TD Bradshaw. Antitumour Benzothiazoles 32. D DNA adducts and double strand breaks correlate with activity; synthesis of 5F 203 hydrogels for local delivery. Bioorganic & Medicinal Chemistry 2015, 23, 6891-6899.
Anchala I. Kuruppu, Lei Zhang, Hilary Collins, Lyudmila Turyanska, Neil R. Thomas and Tracey D. Bradshaw. An apoferritin based drug delivery system for the tyrosine kinase inhibitor Gefitinib. Advanced Healthcare Materials, 2015 4 (18) 2816-2821; DOI 10.1001/adhm.201500389.
J Zhang, M Hummersone, C S Matthews, MFG Stevens, TD Bradshaw. N3-Substituted temozolomide analogues overcome methylguanine-DNA methyltransferase and mismatch repair precipitating apoptotic and autophagic cancer cell death. Oncology 2015, 88, 28-48.
KJ Skilling, A Ndungu,B Kellam, M Ashford, TD Bradshaw, and M Marlow. Gelation properties of self-assembling N-acyl modified cytidine derivatives. J Mat Chem B 2014, 2, 8412-8417
Ramadhan T Othman, Ioanna Kimishi, Tracey D Bradshaw, Lisa CD Storer, Andrey Korshunov, Stefan M Pfister, Richard G Grundy, Ian D Kerr and Beth Coyle. Overcoming multiple drug resistance mechanisms in medulloblastoma. Acta Neuropath Comm 2014 2: 57.
Kathryn J. Skilling, Francesca Citossi, Tracey D. Bradshaw, Marianne Ashford, Barrie Kellam and Maria Marlow. Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications. Soft Matter 2014 10 (2) 237-256.
Tracey D. Bradshaw, Marc Junor, Amalia Patane, Phil Clarke, Neil R. Thomas, Mei Li, Stephen Mann and Lyudmila Turyanska. Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells. J Mat Chem B. 2013 1, 45, 6254-6260.
L Turyanska, TD Bradshaw, M Li, WC Drewe, MW Fay, S Mann, A Patane, NR Thomas. The differential effects of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells. J. Mater. Chem. 2012 22(2) 660–665.
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