Bienemann, Alison

Research Fellow

University of Bristol, UK

Functional Neurosurgery

I am currently working as a research fellow for Professor Steven Gill, Functional Neurosurgery research group.  My main area of expertise is in the progression of translational research towards the clinical setting, utilising both small and large animals models.  

Existing collaborations relevant to drug delivery

Dr Beth Coyle (Nottingham – Children with Cancer Award 2017) Convection enhanced delivery of N3-propargyl, a novel analogue of temozolomide.

Dr Johannes Vomberg (University of Zurich Swiss Cancer Research Fund) Local immunotherapy of brain cancer using an Interleukin-12 Fc fusion cytokine - in vitro refinement, dose escalation and interventional study in spontaneous canine brain tumours.

Other collaborations with Midatech PLC and Renishaw PLC.

Publications relevant to drug delivery

Singleton, W., Bienemann, A., Woolley, M., Johnson, D., Lewis, O., Wyatt, M., Damment, S., Wright, L., Killick-Cole, C., Asby, D., and Gill, S. (2018) The distribution, clearance and brainstem toxicity of panobinostat administered by convection enhanced delivery. Journal of Neurosurgery: Pediatrics

Killick-Cole, C., Singleton, W., Bienemann, A., Asby, D., Myatt, M., Boulter, L., Barua, N., and Gill, S. (2017). Repurposing the anti-epileptic drug sodium valproate as an adjuvant treatment for diffuse intrinsic pontine glioma. PLoS One 12(5): e0176855.

Singleton, W., Collins, A., Bienemann, A., Killick-Cole, C., Haynes, H., Asby, D., Butts, C.P., Wyatt, M.J., Barua, N.U., Gill, S. (2017). Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model. International Journal of Nanomedicine, 12, 1385–1399. http://doi.org/10.2147/IJN.S125300

Arshad, B. Yang, A.S. Bienemann, N.U. Barua,M. Wyatt1, M. Woolley, D.E. Johnson, K.J Edler, (2015) S.S. Gill Convection-Enhanced Delivery of Carboplatin PLGA nanoparticles back after for the treatment of Glioblastoma . Back in review PLoS One

Barua NU, Hopkins K, Woolley M, O'Sullivan S, Harrison R, Edwards RJ, Bienemann AS, Wyatt MJ, Arshad A, Gill SS. (2014). A novel implantable catheter system with transcutaneous port for intermittent convection-enhanced delivery of carboplatin for recurrent glioblastoma. Drug Deliv. 2014 May 2.

Barua NU, Woolley M, Bienemann A S, Johnson D, Wyatt MJ, Irving C, Lewis , Castrique E, Gill SS.(2013). Convection-enhanced delivery of AAV2 in white matter-A novel method for gene delivery to cerebral cortex. J Neurosci Methods. 2013 Oct 30;220(1):1-8.

Kenny GD, Bienemann AS, Tagalakis AD, Pugh JA, Welser K, Campbell F, Tabor AB, Hailes HC, Gill SS, Lythgoe MF, McLeod CW, White EA, Hart SL. (2013).  Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the Brain. Biomaterials. 2013 Dec;34(36):9190-9200.

Gill T, Barua NU, Woolley M, Bienemann AS, Johnson DE, S O'Sullivan, Murray G, Fennelly C, Lewis O, Irving C, Wyatt MJ, Moore P, Gill SS. (2013).   In vitro and in vivo testing of a novel recessed-step catheter for reflux-free convection-enhanced drug delivery to the brain. J Neurosci Methods. 2013 Sep 30;219(1):1-9.

Barua NU, Woolley M, Bienemann AS, Johnson DE, Lewis O, Wyatt MJ, Irving C, O'Sullivan S, Murray G, Fennelly C, Skinner P, Gill SS. (2013).  Intermittent convection-enhanced delivery to the brain through a novel transcutaneous bone-anchored port.J Neurosi Methods. 2013 Apr 15;214(2):223-232.

Bienemann AS,White E,Wooley M, Castrique E,Johnson D, Wyat M,Muray G, Taylor, Barua N, Gill SS. (2012). The development of an implantable catheter system for chronic or intermittent convection-enhanced delivery.J Neurosci Methods. 2012 Jan 30;203(2):284-291 


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