Chair of Molecular Bionics
University College London, UK
Nanomedicine, Cancer targeting, and BBB biophysics
I am the Chair of Molecular Bionics and Honorary Professor of Chemical Engineering in the Department of Chemistry at the University College London. Several of our activities involve the design of novel carriers to target cancer cells and/or cross the blood-brain barrier. We have developed a workflow of activities that allows the design of super-selective nanocarriers, their study in complex in vitro models and finally the pre-clinical validation in relevant models. (See http://www.battagliaresearchgroup.org).
Existing collaborations relevant to drug delivery
We are currently collaborating with Darren Hargrave, Paediatric Neuro-Oncologist at Great Ormond Street Hospital and Reader in Paediatric Neuro-Oncology at the Institute of Child Health, UCL.
We are also collaborating with Prof Paolo Salomoni, previously Professor of Nervous System Tumour Research at UCL and Lead of the Samantha Dickson Brain Cancer Unit and now a group leader at German Centre for Neurodegenerative Diseases (DZNE) in Bonn.
We also have been collaborating for several years with the Blood-Brain Barrier group at King's college led by Prof. Joan Abbott.
Publications relevant to drug delivery
A. Joseph, C. Contini, D. Cecchin, S. Nyberg, L. Ruiz-Perez, J. Gaitzsch, G. Fullstone, X. Tian, J. Azizi, J. Preston, G. Volpe, G. Battaglia*, Chemotactic synthetic vesicles: design and applications in blood brain barrier crossing. Science Adv. 2017, 3, 8, e1700362
X. Tian*, O. Brooks, G. Battaglia*, Pericytes from Mesenchymal Stem Cells to Model for the Blood-Brain Barrier. Sci. Rep. 2017, 7, 39676
G. Fullstone, S. Nyberg, X. Tian, G. Battaglia, From the Blood to the Central Nervous System: A Nanoparticle's Journey Through the Blood–Brain Barrier by Transcytosis. Int. Rev. Neurobiol, 2016, 130, 41–72
G. Yealland, G. Battaglia, O. Bandmann, and H. Mortiboys, Rescue of mitochondrial function in parkin-mutant Fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes. Neurosci. Lett. 2016, S0304-3940(16)30474-8.
X. Tian, S. Nyberg, P. Sharp, J. Madsen, N. Daneshpour, S.P. Armes, J. Berwick, M. Azzouz, P. Shaw, N.J. Abbott and G. Battaglia*, LRP1-mediated intracellular antibody delivery to the Central Nervous System. Sci. Rep. 2015, 5, 11990
R.J. Mead, E. Bennet, P. Sharp, A. Kennerly, C. Sunyach, P. Kasher, J. Berwick, B. Pettmann, G. Battaglia, M. Azzouz, A. Grierson, P.J. Shaw, Optimisation of pre-clinical pharmacology studies in the SOD1G93A transgenic mouse model of Amyotrophic Lateral Sclerosis (ALS). PLoS One 2011 6(8): e23244
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