Professor of Polymer Therapeutics
University of Nottingham, UK
School of Pharmacy
I lead the Division of Molecular Therapeutics and Formulation at the School of Pharmacy in Nottingham. The main areas of research within Polymer Therapeutics are the synthesis and characterisation of bioresponsive materials and externally-activated biosensing and release polymers. These polymers can be triggered to release signals or therapeutic cargoes by heat, light, pH, redox and enzymatic activity.
Existing collaborations relevant to drug delivery
Current projects with Dr Ruman Rahman (Nottingham) on polymer pro-drugs for local delivery (post-surgery) to brain tissue and prior work with Professor David Walker (Nottingham) and Dr Martin Garnett (Nottingham) on 3D spheroid co-cultures to evaluate drug delivery systems.
Publications relevant to drug delivery
Conte, C, Mastrotto, F, Taresco, V, Tchoryk, A, Quaglia, F, Stolnik, S. and Alexander, C. Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environments. Journal of Controlled Release 2018, 277, 126-141.
Makwana, HB, Mastrotto, F, Magnusson, JP, Sleep, D, Hay, J, Nicholls, KJ, Allen, S. and Alexander, C. Engineered Polymer-Transferrin Conjugates as Self-Assembling Targeted Drug Delivery Systems. Biomacromolecules 2017 18(5), 1532–1543.
Ivanov, D, Parker, T, Walker, D, Alexander, C, Ashford, M, Gellert, P. and Garnett, MC. In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment. Journal of Biotechnology. 2015, 205, 3–13.
Ivanov, D, Parker, T, Walker, D, Alexander, C, Ashford, M, Gellert, P. and Garnett, MC. Multiplexing spheroid volume, resazurin and acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheres. PLoS One 2014 9(8): e103817. doi:10.1371/journal.pone.0103817.
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